Nonlinear Modeling and Verification of a Heaving Point Absorber for Wave Energy Conversion [PDF]
, 2017 Although the heaving Point Absorber (PA) concept is well known in wave energy conversion research, few studies focus on appropriate modelling of non-linear fluid viscous and mechanical friction dynamics.
Gilbert, James +4 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Mathematical modelling of the cardiovascular system
, 2002 In this paper we will address the problem of developing mathematical models for the numerical simulation of the human circulatory system.
Quarteroni, Alfio
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Computation of irradiance in a solar still by using a refined algorithm [PDF]
, 2013 A refined solar algorithm from the ESP-r system has been used to calculate the distribution of solar irradiation inside a basin-type solar still. In the approach, surface finish, view factors and multiple reflections are taken into consideration in the ...
Clarke, Joseph Andrew, Madhlopa, Amos
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Parsimonious numerical modelling of deep geothermal reservoirs [PDF]
, 2015 Numerical modelling has been undertaken to help improve understanding of a deep geothermal system being considered for development in the vicinity of Eastgate (Weardale, County Durham, UK).
Fairs, Tim H. +2 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Calibration of NSRP Models from Extreme Value Distributions
Hydrology, 2019 In this work, the authors investigated the feasibility of calibrating a model which is suitable for the generation of continuous high-resolution rainfall series, by using only data from annual maximum rainfall (AMR) series, which are usually longer than ...
Davide Luciano De Luca, Luciano Galasso
doaj +1 more source
Development of a vehicle robotic driver with intelligent control system modelling for automated standard driving-cycle tests [PDF]
, 2019 New road vehicles are required to undergo several specific tests to meet the requirement set by governing bodies in various markets. These tests are often carried out over specific driving-cycles.
Mohammed Mahdi, Ammar Abdo
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