Results 61 to 70 of about 171,168 (299)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Optimization of spatial arrangement of magnetic field sensors of closed loop system of overhead power lines magnetic field active silencing

Electrical engineering & Electromechanics, 2023
Aim. Development of a method for optimization of spatial arrangement and angular position of magnetic field sensors of a closed system to ensure maximum efficiency of active silencing canceling of the magnetic field generated by overhead power lines ...
B. I. Kuznetsov, T. B. Nikitina, I. V. Bovdui, O. V. Voloshko, V. V. Kolomiets, B. B. Kobylianskyi   +5 more
doaj   +1 more source

Experimental active and passive dosimetry systems for the NASA Skylab program [PDF]

, 1972
Active and passive dosimetry instrumentation to measure absorbed dose, charged particle spectra, and linear energy transfer spectra inside the command module and orbital workshop on the Skylab program were developed and tested.
Ainsworth, G. C., Janni, J. F., Schneider, M. F.   +2 more
core   +1 more source

The magnetic shielding for the neutron decay spectrometer aSPECT

, 2014
Many experiments in nuclear and neutron physics are confronted with the problem that they use a superconducting magnetic spectrometer which potentially affects other experiments by their stray magnetic field. The retardation spectrometer aSPECT consists,
Baeßler, Stefan, Borg, Michael, Glück, Ferenc, Guardia, Fidel Ayala, Heil, Werner, Hiebel, Stefan, Horta, Raquel Munoz, Konrad, Gertrud, Sobolev, Yury   +8 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Reducing the Magnetic Field Level of Single-Circuit Overhead Power Lines in Multi-Storey Buildings by Means of Active and Passive Shielding [PDF]

Problems of the Regional Energetics
The purpose of the work is a theoretical and experimental study of the effectiveness of combined shielding, including active and passive shielding using a continuous screen, of the magnetic field generated by single-circuit power lines with a triangular ...
Kuznetsov B.I., Kutsenko A.S., Nikitina T.B., Bovdui I.V., Chunikhin K.V., Voloshko O.V.   +5 more
doaj   +1 more source

A CsI(Tl) Scintillating Crystal Detector for the Studies of Low Energy Neutrino Interactions [PDF]

, 2000
Scintillating crystal detector may offer some potential advantages in the low-energy, low-background experiments. A 500 kg CsI(Tl) detector to be placed near the core of Nuclear Power Station II in Taiwan is being constructed for the studies of electron ...
Achkar, Achkar, Afonin, Alarja, Alexeev, Allen, Allen, Amsler, Apollonio, Armbruster, Avenier, B.A. Zhuang, Barabanov, Barbieri, Belli, Bernabei, Bernabéu, Bernstein, Broggini, C.C. Chang, C.P. Chen, C.W. Wang, C.Y. Chang, Chang, Chang, Charalambus, Chipaux, Cocconi, Conrad, D.X. Zhao, Derbin, Donnelly, Ejiri, Ellis, Fukugita, Fushimi, G.C. Kiang, Garvey, Gerbier, Goodman, Grassman, Gratta, Greenwood, Groom, Gunji, H.B. Li, H.T. Wong, H.Y. Sheng, Hayakawa, Ishii, J. Li, J.G. Lu, J.H. Chao, Jenkins, Kaplan, Kayser, Kilgus, Kotthaus, Kozlowski, Krauss, Kreutz, Kubodera, Kyuldjiev, L. Hou, Lanou, Lattimer, Lee, M. He, Mikheyev, Morgan, Morris, Notzold, P.K. Teng, Pasierb, R.F. Su, Raffelt, Raghavan, Raghavan, Raghavan, Reines, Riley, S.C. Lee, S.C. Wang, S.Q. Zhao, Sarsa, Schaller, Schotanus, Spooner, Suffert, Sutherland, Suzuki, T.R. Yeh, T.Y. Chen, Vidyakin, Vidyakin, Vidyakin, Vidyakin, Vilain, Vogel, Voloshin, W.P. Lai, Wolfenstein, Wong, Wong, Y. Liu, Z.P. Mao, Z.Y. Zhang, Z.Y. Zhou, Zacek, Zucker   +109 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Scanning of Vehicles for Nuclear Materials

, 2013
Might a nuclear-armed terrorist group or state use ordinary commerce to deliver a nuclear weapon by smuggling it in a cargo container or vehicle? This delivery method would be the only one available to a sub-state actor, and it might enable a state to ...
Katz, J. I.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source