Results 141 to 150 of about 304,833 (302)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

On the behaviour of the solutions of a $k$-order cyclic-type system of max difference equations

summary:We investigate the behaviour of the solutions of a $k$-dimensional cyclic system of difference equations with maximum. More precisely, we study the existence and the number of the equilibria in the case when $k$ is an odd or an even positive ...
Stefanidou, Gesthimani, Papaschinopoulos, Garyfalos   +1 more
core   +1 more source

Numerical Solutions for Multi-Term Fractional Order Differential Equations with Fractional Taylor Operational Matrix of Fractional Integration

, 2020
In this article, we propose a numerical method based on the fractional Taylor vector for solving multi-term fractional differential equations. The main idea of this method is to reduce the given problems to a set of algebraic equations by utilizing the ...
İbrahim Avcı, Nazim I. Mahmudov
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Solvability of Three-Dimensional Nonlinear Difference Systems via Transformations and Generalized Fibonacci Recursions

Mathematics
This paper presents closed-form solutions for a three-dimensional system of nonlinear difference equations with variable coefficients. The approach employs functional transformations and leverages generalized Fibonacci sequences to construct the ...
Yasser Almoteri, Ahmed Ghezal
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Algebraic Reduction and Periodic Solvability in a Coupled Ternary Rational System

Mathematics
In this paper, we investigate a new class of three-component nonlinear rational difference equations of the second order characterized by structured periodic interactions.
Ahmed Ghezal, Ahmed A. Al Ghafli, Hassan J. Al Salman   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Solvable product-type system of difference equations of second order

Electronic Journal of Differential Equations, 2015
We show that the system of difference equations $$ z_{n+1}=\frac{w_n^a}{z_{n-1}^b},\quad w_{n+1}=\frac{z_n^c}{w_{n-1}^d},\quad n\in\mathbb{N}_0, $$ where $a,b,c,d\in\mathbb{Z}$, and initial values $z_{-1}, z_0, w_{-1}, w_0\in\mathbb{C}$, is ...
Stevo Stevic, Mohammed A. Alghamdi, Abdullah Alotaibi, Elsayed M. Elsayed   +3 more
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source