Results 41 to 50 of about 279,696 (263)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Stability of the Exponential Type System of Stochastic Difference Equations
Mathematics, 2023 The method of studying the stability in the probability for nonlinear systems of stochastic difference equations is demonstrated on two systems with exponential and fractional nonlinearities.
Leonid Shaikhet
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
A note on general solutions to a hyperbolic-cotangent class of systems of difference equations
Advances in Difference Equations, 2020 Recently there has been some interest in difference equations and systems whose forms resemble some trigonometric formulas. One of the classes of such systems is the so-called hyperbolic-cotangent class of systems of difference equations.
Stevo Stević
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
On a two-dimensional solvable system of difference equations
Electronic Journal of Qualitative Theory of Differential Equations, 2018 Here we solve the following system of difference equations $$x_{n+1}=\frac{y_ny_{n-2}}{bx_{n-1}+ay_{n-2}},\quad y_{n+1}=\frac{x_nx_{n-2}}{dy_{n-1}+cx_{n-2}},\quad n\in\mathbb{N}_0,$$ where parameters $a, b, c, d$ and initial values $x_{-j},$ $y_{-j}$, $j=
Stevo Stevic
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
A k-Dimensional System of Fractional Finite Difference Equations
Abstract and Applied Analysis, 2014 We investigate the existence of solutions for a k-dimensional system of fractional finite difference equations by using the Kranoselskii’s fixed point theorem. We present an example in order to illustrate our results.
Dumitru Baleanu +2 more
doaj +1 more source
Trichotomy of a system of two difference equations
Journal of Mathematical Analysis and Applications, 2004 The authors study the boundedness and asymptotic behavior of positive solutions of the system of difference equations \[ x_{n+1}=A+\frac{\sum_{i=1}^{k} a_ix_{n-p_i}}{\sum_{j=1}^{m}b_jy_{n-q_j}},\qquad y_{n+1}=B+\frac{\sum_{i=1}^{k} c_iy_{n-p_i}}{\sum_{j=1}^{m}d_jx_{n-q_j}}, \] and obtain some results, where \(k, m\in \{1, 2, \ldots\}, A, B, a_i, c_i ...
Papaschinopoulos, G., Stefanidou, G.
openaire +2 more sources