Results 41 to 50 of about 151,638 (261)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

General decay estimate for coupled plate problem with memory

Results in Applied Mathematics, 2022
This article considers a coupled system of non-linear plate equations with partially hinged boundary conditions. By assuming general conditions on the relaxation functions, we show that the associated energy functional satisfy a general decay estimate ...
Soh Edwin Mukiawa, McSylvester Ejighikeme Omaba, Cyril Dennis Enyi, Tijani A. Apalara   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Unstable (Stable) system of stable (unstable) functional equations

Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2010
In this note the answer to a question by Z. Moszner from the paper [1] about connections of stability of separate equations and the system of them, is given.
Zenon Moszner, Andrzej Mach
doaj  

Linear Approximation And Asymptotic Expansion Associated With The System Of Nonlinear Functional Equations

Demonstratio Mathematica, 2014
This paper is devoted to the study of the following perturbed system of nonlinear functional equations x ∊Ω=[-b,b], i = 1,…., n; where ε is a small parameter, aijk; bijk are the given real constants, Rijk, Sijk , Xijk : Ω → Ω ,gi → Ω →ℝ , Ψ: Ω x ℝ2→ ℝ ...
Ngoc Le Thi Phuong, Dung Huynh Thi Hoang, Danh Pham Hong, Long Nguyen Thanh   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Computational methods and dynamical analysis for studying ( 1 + 1 ) $(1 + 1)$ dimensional functional equations of mixed integro-differential type

Boundary Value Problems
In the present paper, the Fibonacci collocation method is implemented to solve ( 1 + 1 ) $(1 + 1)$ dimensional difference equations of mixed integro-differential type.
Amr M. S. Mahdy, Mohamed A. Abdou, Doaa S. Mohamed   +2 more
doaj   +1 more source