Results 61 to 70 of about 151,638 (261)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
, 2020 Motivated by Lazer-Leach type results, we study the existence of periodic solutions for systems of functional-differential equations at resonance with an arbitrary even-dimensional kernel and linear deviating terms involving a general delay of the form $\int_0^{2π}u(t+s)\,dλ(s)$, where $λ$ is a finite regular signed measure. Our main technique shall be
Amster, Pablo +2 more
openaire +2 more sources
Karpatsʹkì Matematičnì Publìkacìï, 2011 The article shows that the system of the functional equations$S(x+y)=S(x)C(y)+S(y)C(x),,C(x+y)=C(x)C(y)-S(y)S(x)$ defines abroader class of the functions than the trigonometric equations.
Е. V. Velichko, I. G. Tkachenko
doaj
A Pexider system of additive functional equations in Banach algebras
Journal of Inequalities and ApplicationsIn this paper, we solve the system of functional equations { f ( x + y ) + g ( y − x ) = 2 f ( x ) , g ( x + y ) − f ( y − x ) = 2 g ( y ) $$\begin{aligned} \textstyle\begin{cases} f(x+y)+g(y-x)=2f(x), \\ g(x+y)-f(y-x)=2g(y) \end{cases}\displaystyle \end{
Mehdi Dehghanian +3 more
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Steady heat conduction of material with coated inclusion in the case of imperfect contact
Mathematical Modelling and Analysis, 2007 We discuss a potential steady heat conduction for composites with the coated cylindrical inclusion under an imperfect contact condition. We rewrite equivalently the considered problem to a conjugation problem for analytic functions which is reduced then ...
Paweł Drygas
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Infinite Systems of Hyperbolic Functional Differential Equations [PDF]
Ukrainian Mathematical Journal, 2003 Summary: We consider initial-value problems for infinite systems of first-order partial functional differential equations. The unknown function is the functional argument in equations and the partial derivations appear in the classical sense. A theorem on the existence of a solution and its continuous dependence upon initial data is proved.
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source