Results 71 to 80 of about 164,099 (264)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Periodic solutions for a system of nonlinear neutral functional difference equations with two functional delays [PDF]

Mathematica Moravica, 2015
In this paper, we study the existence and uniqueness of periodic solutions of the system of nonlinear neutral difference equations ∆x (n) = A(n) x (n - t (n)) + ∆Q(n; x (n - g (n))) + G(n; x (n) ; x (n - g (n))).
Mesmouli Billah Mouataz, Ardjouni Abdelouaheb, Djoudi Ahcene   +2 more
doaj  

Infinite Systems of Hyperbolic Functional Differential Equations [PDF]

Ukrainian Mathematical Journal, 2003
Summary: We consider initial-value problems for infinite systems of first-order partial functional differential equations. The unknown function is the functional argument in equations and the partial derivations appear in the classical sense. A theorem on the existence of a solution and its continuous dependence upon initial data is proved.
openaire   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Pexider system of additive functional equations in Banach algebras

Journal of Inequalities and Applications
In this paper, we solve the system of functional equations { f ( x + y ) + g ( y − x ) = 2 f ( x ) , g ( x + y ) − f ( y − x ) = 2 g ( y ) $$\begin{aligned} \textstyle\begin{cases} f(x+y)+g(y-x)=2f(x), \\ g(x+y)-f(y-x)=2g(y) \end{cases}\displaystyle \end{
Mehdi Dehghanian, Yamin Sayyari, Siriluk Donganont, Choonkil Park   +3 more
doaj   +1 more source

The Stability of Bi-Drygas Functional Equation [PDF]

Sahand Communications in Mathematical Analysis
In this paper, we introduce and solve a system of bi-Drygas functional equations \begin{equation}\left\{\begin{aligned}        &f(x+y,z)+f(x-y,z)=2f(x,z)+f(y,z)+f(-y,-z)\nonumber\\        &f(x,y+z)+f(x, y-z)=2f(x,y)+f(x,z)+f(-x,-z)\nonumber\end{aligned ...
Mehdi Dehghanian, Sadegh Izadi, Yamin Sayyari   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

On the correctness of the determination of trigonometric functions by the system of functional equations

Karpatsʹkì Matematičnì Publìkacìï, 2011
The article shows that the system of the functional equations$S(x+y)=S(x)C(y)+S(y)C(x),,C(x+y)=C(x)C(y)-S(y)S(x)$ defines abroader class of the functions than the trigonometric equations.
Е. V. Velichko, I. G. Tkachenko
doaj