Results 91 to 100 of about 151,638 (261)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Conservation Laws of Discrete Korteweg-de Vries Equation
Symmetry, Integrability and Geometry: Methods and Applications, 2005 All three-point and five-point conservation laws for the discrete Korteweg-de Vries equations are found. These conservation laws satisfy a functional equation, which we solve by reducing it to a system of partial differential equations.
Olexandr G. Rasin, Peter E. Hydon
doaj
Abstract and Applied Analysis, 2014 The modified generalized Laguerre-Gauss collocation (MGLC) method is applied to obtain an approximate solution of fractional neutral functional-differential equations with proportional delays on the half-line.
Ali H. Bhrawy +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Integrable Systems with Pairwise Interactions and Functional Equations
, 1994 32 pages latex2e. Some Proofs removed.
Braden, H. W., Buchstaber, V. M.
openaire +3 more sources
On the equivalence of pre-Schröder equations [PDF]
Opuscula Mathematica, 2007 In the paper the equivalence of the system of two pre-Schröder functional equations (equations \((S_n)\), \((S_m)\) for \(m \gt n \geq 3\), \(n, m \in \mathbb{N}\)) and the whole system \((S)\), is considered.
Józef Kalinowski
doaj
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source