Results 81 to 90 of about 926,088 (241)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Weak solutions to problems involving inviscid fluids

, 2015
We consider an abstract functional-differential equation derived from the pressure-less Euler system with variable coefficients that includes several systems of partial differential equations arising in the fluid mechanics.
C Audiard, C Lellis De, CM Dafermos, CM Dafermos, D Bresch, E Chiodaroli, E Chiodaroli, J Lowengrub, L Desvillettes, M Kotschote, M Kotschote, P Antonelli, P Antonelli, S Benzoni-Gavage, S Benzoni-Gavage   +14 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A complete set of equations for piezo-magnetoelastic analysis of a functionally graded thick shell of revolution

Latin American Journal of Solids and Structures
Tensor analysis and an orthogonal curvilinear coordinate system have been used to derive a complete set of equations for piezo-magneto-elastic analysis of a functionally graded (FG) thick shell of revolution with variable thickness and curvature.
Mohammad Arefi
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Existence Theorem for Integral and Functional Integral Equations with Discontinuous Kernels

Abstract and Applied Analysis, 2012
Existence of extremal solutions of nonlinear discontinuous integral equations of Volterra type is proved. This result is extended herein to functional Volterra integral equations (FVIEs) and to a system of discontinuous VIEs as well.
Ezzat R. Hassan
doaj   +1 more source

QQ-system and non-linear integral equations for scattering amplitudes at strong coupling

Journal of High Energy Physics, 2020
We provide the two fundamental sets of functional relations which describe the strong coupling limit in AdS 3 of scattering amplitudes in N $$ \mathcal{N} $$ = 4 SYM dual to Wilson loops (possibly extended by a non-zero twist l): the basic QQ-system and ...
Davide Fioravanti, Marco Rossi, Hongfei Shu   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Approximate Controllability for Functional Equations with Riemann-Liouville Derivative by Iterative and Approximate Method

Journal of Function Spaces, 2017
We discuss the functional control systems governed by differential equations with Riemann-Liouville fractional derivative in general Banach spaces in the present paper.
Badawi Hamza Elbadawi Ibrahim, Zhenbin Fan, Gang Li   +2 more
doaj   +1 more source