Results 81 to 90 of about 164,099 (264)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Steady heat conduction of material with coated inclusion in the case of imperfect contact

Mathematical Modelling and Analysis, 2007
We discuss a potential steady heat conduction for composites with the coated cylindrical inclusion under an imperfect contact condition. We rewrite equivalently the considered problem to a conjugation problem for analytic functions which is reduced then ...
Paweł Drygas
doaj   +1 more source

On the existence of solutions of systems of functional differential equations [PDF]

Proceedings of the American Mathematical Society, 1954
where the symbol Y(x) stands for the set of functions {yh(Uk(X)) I (h = 1, * * *, n; k = 1, * * *, m). Under prescribed initial conditions this system is to be solved for the y's as functions of x. The functions fi, * * , f,n are given, and the functions ul(x), * * *, um(x) are also given.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Solutions and approximations of a system of cubic reciprocal functional equations

Journal of Inequalities and Applications
In this paper, we propose two novel rational forms of multiplicative inverse cubic functional equations. We extended these equations to multicubic reciprocal functional equations and determined their general solutions in restricted domains.
Abasalt Bodaghi, Beri Venkatachalapathy Senthil Kumar   +1 more
doaj   +1 more source

On One Damping Problem for a Nonstationary Control System with Aftereffect

Современная математика: Фундаментальные направления, 2019
We consider a control system described by the system of differential-difference equations of neutral type with variable matrix coefficients and several delays.
A. S. Adkhamova, A. L. Skubachevskii
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A complete set of equations for piezo-magnetoelastic analysis of a functionally graded thick shell of revolution

Latin American Journal of Solids and Structures
Tensor analysis and an orthogonal curvilinear coordinate system have been used to derive a complete set of equations for piezo-magneto-elastic analysis of a functionally graded (FG) thick shell of revolution with variable thickness and curvature.
Mohammad Arefi
doaj   +1 more source