Results 161 to 170 of about 170,074,763 (296)

A domain-specific annotation framework and expert-annotated corpus for structured analysis of German HNSCC pathology reports. [PDF]

BMC Res Notes
Gubik S, Seger F, Vollmer A, Hörner M, Renner T, Kohlhepp L, Manthey M, Müller-Richter U, Kübler A, Hackenberg S, Hartmann S.   +10 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

International Forum on the Prevention of ABO Incompatible Red Blood Cell Transfusion: Responses. [PDF]

Vox Sang
Mirrione-Savin A, Murphy MF, Schäfer R, Tiberghien P, Arora S, Dua S, Mueller MM, Tonn T, Diop S, Seck M, Alarimi ZAF, Badawi MA, Sato T, Miyajima A, Wendel S, Fachini R, Petraszko T, Mack J, Cuppari I, Prati D, Nuñez MA, Saa E, Cohn CS, Engel BS, Wood E, Daly J, Ji Y, Zhao Y, Delettre FA, Bourcier V, Pons V, Espasa A, van der Merwe W, Wessels PL, Owusu-Ofori S, John-Teye D, Narayan S, Swarbrick N, Al-Riyami AZ, Dunbar N.   +39 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Development and validation of a MedDRA-based signal detection construct for drug-induced neurobehavioral impairment. [PDF]

Ther Adv Drug Saf
Breder CD.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Brain network topology and neural mechanisms in Sanda athletes: a comparative study across training levels. [PDF]

Front Neurosci
Chen Y, Jia Z, Zhao Z, Zhou J, Lin Y, Zhao B.   +5 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

An investigation of techniques that aim to improve the quality of labels provided by the crowd

The 2013 MediaEval Crowdsourcing task looked at the problem of working with noisy crowdsourced annotations of image data. The aim of the task was to investigate possible techniques for estimating the true labels of an image by using the set of noisy ...
Weston, Anna, Simperl, E., Acosta, Maribel, Samangooei, Sina, Hare, Jonathon, Dupplaw, David, Lewis, Paul H.   +6 more
core   +1 more source

Consistency-Aware Weakly Supervised Anomaly Sensing for Large-Scale Expressway ETC Gantry Transactions. [PDF]

Sensors (Basel)
Li Y, Jiang H, Xu X, Zyryanov V.
europepmc   +1 more source