Results 111 to 120 of about 313,126 (308)

Spectral characteristics of a nonlocal problem for two linear systems of partial differential equations

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2017
We study the boundary-value problem for a linear system of differential equations written in the form of differential-operator equations $$ aD_t u(t)+bBu(t)=f(t) $$ with nonlocal boundary conditions at $t$.
Dmitriy V Kornienko
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The inclusion of additional topics to the program of linear algebra course for economists and managers

Развитие образования, 2019
The paper generalizes the concept of “solving a system of linear algebraic equations in order to formulate a unified approach to the analysis of incompatible, indefinite and unstable systems”.
Sergej Y. Shashkin
doaj   +1 more source

The linear quadratic regulator problem for a class of controlled systems modeled by singularly perturbed Ito differential equations

, 2012
Link to a related website: https://digital.library.adelaide.edu.au/dspace/bitstream/2440/77907/1/hdl_77907.pdf, Open Access via UnpaywallThis paper discusses an infinite-horizon linear quadratic (LQ) optimal control problem involving state- and control ...
Shi, Peng, Mukaidani, Hiroaki, Dragan, V., Mukaidani, H., Dragan, Vasile, Shi, P.   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Projection schemes for stochastic partial differential equations

, 2009
The focus of the present work is to develop stochastic reduced basis methods (SRBMs) for solving partial differential equations (PDEs) defined on random domains and nonlinear stochastic PDEs (SPDEs).
Prerapa, Surya Mohan
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Parametric analysis of acoustic liner in bicameral duct: An analytical perspective

Partial Differential Equations in Applied Mathematics
Parametric analysis of different choices of acoustic absorbent liners in a bicameral acoustic duct is presented in the current research study. Bicameral is characterized by two expansion chambers but functions as a single duct in practice, that is widely
Sajid Shafique, Muhammad Afzal, Muhammad Arsalan Ahmad, Mohammad Mahtab Alam   +3 more
doaj   +1 more source

Modeling crowd dynamics through hyperbolic - elliptic equations

, 2018
Inspired by the works of Hughes [22, 23], we formalize and prove the well-posedness of a hyperbolic–elliptic system whose solutions describe the dynamics of a moving crowd.
Massimiliano Rosini, Rinaldo M. Colombo, Rinaldo Colombo, Massimiliano D. Rosini, Gokieli, Maria, Colombo, Rinaldo M., Rosini, Massimiliano D., Maria Gokieli   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source