Results 71 to 80 of about 247,997 (332)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The Goursat problem for one hyperbolic system of the third order differential equations with two independent variables

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
The solution of the Goursat problem for the system of the differential equations of the third order is received on the basis of Riemann method. The Riemann matrix expressed in terms of hypergeometric functions with matrix argument is received, using it ...
J. O. Yakovleva, A. A. Andreev
doaj   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Linear systems and determinantal random point fields. [PDF]

open access: yes, 2008
Tracy and Widom showed that fundamentally important kernels in random matrix theory arise from systems of differential equations with rational coefficient.
Blower, Gordon
core   +1 more source

On the Polar Equations for Linear Systems and Related Nonlinear Matrix Differential Equations [PDF]

open access: yesTransactions of the American Mathematical Society, 1965
0. Introduction. This paper is devoted to laying the groundwork for a theory of matrix differential equations and associated linear systems. The fundamental problem is that of characterizing the solutions of general linear systems from the coefficient matrices themselves.
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Positivity of Fundamental Matrix and Exponential Stability of Delay Differential System

open access: yesAbstract and Applied Analysis, 2014
The classical Wazewski theorem established that nonpositivity of all nondiagonal elements pij  (i≠j,  i,j=1,…,n) is necessary and sufficient for nonnegativity of the fundamental (Cauchy) matrix and consequently for applicability of the Chaplygin approach
Alexander Domoshnitsky   +3 more
doaj   +1 more source

A new form of equations of motion of nonholonomic mechanical systems

open access: yesVietnam Journal of Mechanics, 1997
In the paper it is given a new form of equations of motion of nonholonomic mechanical systems. The obtained equations are written in a matrix form and in order to establish them it is unnecessary to calculate the inverse matrix of the matrix of inertia.
Do Sanh
doaj   +1 more source

Construction of Open-Loop Electromechanical System Fundamental Matrix and Its Application for Calculation of State Variables Transients

open access: yesEnergy Engineering and Control Systems, 2020
The article considers the methods of calculating the transition matrix of a dynamic system, which is based on the transient matrix representation by the matrix exponent and on the use of the system signal graph.
Orest Lozynskyy   +4 more
doaj   +1 more source

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