Results 131 to 140 of about 3,794,455 (268)

Mature-Aged People in the Rural Health Workforce System: A Systems Modelling Approach. [PDF]

Aust J Rural Health
Quilliam C, Thompson J, Crawford N, McKinstry C, Chambers A, Bhat R, Stanbrook L.   +6 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Addressing the Increasing Rate of Caesarean Sections in an Australian Healthcare System: A Systems Science Approach to Identify Stakeholder Perspectives. [PDF]

Nurs Health Sci
O'Halloran S, Perlen S, Chapman A, Luba S, Dawson SL, Cusworth R, Alston L, Vasilevski V, Sweet L, Vuillermin P, Hutchinson AM, Pregnancy Research and Translation Ecosystem Investigator group.   +11 more
europepmc   +1 more source

Injury surveillance as a distributed system of systems. [PDF]

Inj Prev, 2016
McClure RJ, Mack K.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Research Domain Criteria (RDoC) domains positive valence system, negative valence system, cognitive systems, and social processes and their relationship with stress, anxiety, and depressive symptoms in a university student sample. [PDF]

Front Psychiatry
Esipova V, Tschorn M, Böttger SJ, Seiffert J, Förstner B, Seegert T, Rapp MA, Koller-Schlaud K.   +7 more
europepmc   +1 more source

A System-of-Systems Bio-Inspired Design Process: Conceptual Design and Physical Prototype of a Reconfigurable Robot Capable of Multi-Modal Locomotion. [PDF]

Front Neurorobot, 2019
Tan N, Sun Z, Mohan RE, Brahmananthan N, Venkataraman S, Sosa R, Wood K.   +6 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Understanding Water-Stress Responses in Soybean Using Hydroponics System-A Systems Biology Perspective. [PDF]

Front Plant Sci, 2015
Tripathi P, Rabara RC, Shulaev V, Shen QJ, Rushton PJ.   +4 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source