Results 101 to 110 of about 6,357 (258)

Verbal Signs of Value: Selection Principles during Axiological Construction in Contemporary Speech Practice

Известия Уральского федерального университета. Серия 2: Гуманитарные науки, 2015
The authors consider the socially relevant problem of axiological construction during a conflict of values. Referring to the lexical combinatory power of the word ценности (values) the authors reveal Russian people’s need to protect the system of basic ...
Irina Trofimovna Vepreva, Nataliya Aleksandrovna Kupina   +1 more
doaj  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

PLACE AND ROLE OF PHYSICAL UPBRINGING IN THE SYSTEM OF EDUCATIONAL INSTITUTIONS OF RUSSIA: HISTORY AND MODERNITY

, 2019
The article considers the system of physical education, which actively contributes to the formation of a full-fledged personality with its physical aesthetic and moral virtues, which is a socially useful activity for the organization of leisure of people. It is shown that sport is the most effective means of preventive work of various diseases.
openaire   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

UPBRINGING WORK OF THE UNIVERSITY CURATOR IN THE CONTEXT OF GLOBALIZATION: THE SOCIO-PHILOSOPHICAL ANALYSIS OF THE CRISIS IN THE EDUCATIONAL SYSTEM

Siberian Medical Review, 2014
Abstract. This article analyzes the problems of the upbringing work of the university curator in the context of globalization and suggests the practical steps to solve them. Key words: absenteeism, educational work, globalization, curator, general cultural competence.I.
openaire   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

COEVOLUTIONARY APPROACH IN THE SYSTEM OF ECOLOGICAL EDUCATION AND UPBRINGING [PDF]

Современные наукоемкие технологии (Modern High Technologies), 2019
openaire   +1 more source

ADVANCED VIEWS OF TURKESTAN REFORMERS ON THE MODERNIZATION OF THE EDUCATION AND UPBRINGING SYSTEM

This article discusses the ideas of Turkestan reformers concerning the modernization of social life through the development of education and upbringing, their efforts to awaken national consciousness, establish new-method schools, and reform the content of education, as well as their views on women’s education and upbringing, its goals and main ...
openaire   +1 more source