Results 191 to 200 of about 6,357 (258)

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Transnational intergenerational relationships and doing transcultural family through mandarin learning: an ethnographic glance at Chinese dynamics in four intercultural families in Germany. [PDF]

Front Sociol
Li-Gottwald J.
europepmc   +1 more source

Dynamic Single‐Binding Event Profiling With on‐Chip Microlenses for Wash‐Free Digital Biosensing

Advanced Science, EarlyView.
A microlens‐enhanced platform enables real‐time tracking and digital counting of single‐binding events using conventional bright‐field microscopy. Amplified scattering signals from gold nanoparticle labels and kinetic signature analysis allow wash‐free discrimination between specific and nonspecific interactions, while providing kinetic and mechanistic
Tingting Zhan, Lianyu Lu, Guoqiang Gu, Pengcheng Zhang, Jienan Shen, Xiaotian Tan, Wei Ye, Shi Hu, Yi Zhang, Hao Yu, Shaoqin Liu, Hairong Zheng, Hui Yang   +12 more
wiley   +1 more source

Social Determinants of Health and 30-Day Readmission for Heart Failure Patients in U.S. Hospitals: Evidence from ICD-10 Z-Code Data. [PDF]

Healthcare (Basel)
Cai Y, Yanping L, Liu Q.
europepmc   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Urbanicity, parental social deprivation, and risk of early psychosis in Chile: a national cohort study. [PDF]

Lancet Reg Health Am
Mascayano F, Burgos J, Hernandez V, Casanueva R, Yang X, Li Z, Sampat P, Muñoz-Quezada MT, Rojas-Navarro S, Rodriguez K, Stingone J, Yang L, Susser E.   +12 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Influences of Western Cape community service doctors' choice regarding public, rural practice. [PDF]

S Afr Fam Pract (2004)
Baytopp TJ, Lomas-Marais V, Motsohi T.
europepmc   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Career choices in graduates from the Taipei Third Girls high school in 1936 - With special emphasis on those hoping to study dentistry. [PDF]

J Dent Sci
Cheng FC, Wang LH, Chiang CP.
europepmc   +1 more source