Results 31 to 40 of about 11,495 (245)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Modern guidelines for the conceptualization of personal development and upbringing in higher education [PDF]

Известия Саратовского университета. Новая серия: Акмеология образования. Психология развития
The relevance of the research is determined by the necessity to conceptualize the educational process at universities in new social and cultural conditions that are accompanied by challenges to Russian education.
Selivanova, Natalia L., Shakurova, Marina V.   +1 more
doaj   +1 more source

Maksim Kovalevsky’s ideas on the education and upbringing of youth

, 2020
In the article, Maksim Kovalevsky’s work is considered as a prehistory of Russian youth sociology. His understanding of the essence of upbringing is analyzed (not grouping everyone under one pattern, but the development of individual characteristics ...
Chevtaeva, Natalya G., Vishnevsky, Yuri R., Narkhov, Dmitry Yu.   +2 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Effectiveness of Learning Management Systems (LMS) in Developing the Education and Upbringing Process [PDF]

, 2017
This paper aims to identify the aspects of the effectiveness of learning management system which has been taking a role to develop the education and upbringing process, so that it has explained the concept of Learning Management Systems as well as its ...
Alwaili, Haya Abdullah, Alhazzani, Nada Abdullah, Alzouman, Arwa Sulaiman   +2 more
core   +1 more source

The Characteristics of the Educator and the Learner in a Curriculum Based on the Hayat Tayyibah Approach [PDF]

علوم تربیتی از دیدگاه اسلام
According to the Fundamental Transformation Document, the role of the educator as a guide, a trustworthy and insightful exemplar in the process of education and upbringing, and the most influential element in realizing the missions of the country’s ...
rahmat marzoghi, farzane deimehkar haghighi   +1 more
doaj   +1 more source

Religious Education in Denmark: Towards a More Multifaceted Subject?

Religions, 2020
The article deals with religious education in Denmark, especially the impact of philosophy of life in the curriculum. It will address the question of whether “Christian Studies” has become more multifaceted, or whether it is really a Christian upbringing/
Pia Rose Böwadt
doaj   +1 more source

Psychological issues of education of kindergarten children and school children in the information society [PDF]

Национальный психологический журнал, 2018
Background. The issue of upbringing is becoming increasingly important due to the development and growing-up of modern children and adolescents in the so-called digital age.
Irina V. Dubrovina
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source