Results 31 to 40 of about 6,357 (258)

UPBRINGING AS A MEANS OF THE LIFE CREATION IN ITS BEST POINTS

Образование и наука, 2015
The research is aimed at emphasizing the updating necessity of pastoral work in Russian schools and universities due to changed economic, social and ideological conditions of development of a society. Methods. The research involves the method of socially-
Leonid I. Luriye
doaj   +1 more source

Experience in Pedagogical Design of the System of Social Upbringing in an Educational Organization

Review of Omsk State Pedagogical University. Humanitarian research, 2023
The article reveals the practice of designing a local system of social upbringing for a secondary school on the example of Secondary School No. 41 in Omsk. In the course of the study, a project for a system of social upbringing in a secondary general school was developed, taking into account the characteristics of the microenvironment.
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Modern guidelines for the conceptualization of personal development and upbringing in higher education [PDF]

Известия Саратовского университета. Новая серия: Акмеология образования. Психология развития
The relevance of the research is determined by the necessity to conceptualize the educational process at universities in new social and cultural conditions that are accompanied by challenges to Russian education.
Selivanova, Natalia L., Shakurova, Marina V.   +1 more
doaj   +1 more source

Psychological issues of education of kindergarten children and school children in the information society [PDF]

Национальный психологический журнал, 2018
Background. The issue of upbringing is becoming increasingly important due to the development and growing-up of modern children and adolescents in the so-called digital age.
Irina V. Dubrovina
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The Characteristics of the Educator and the Learner in a Curriculum Based on the Hayat Tayyibah Approach [PDF]

علوم تربیتی از دیدگاه اسلام
According to the Fundamental Transformation Document, the role of the educator as a guide, a trustworthy and insightful exemplar in the process of education and upbringing, and the most influential element in realizing the missions of the country’s ...
rahmat marzoghi, farzane deimehkar haghighi   +1 more
doaj   +1 more source