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Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger +2 more
wiley +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source

A Digital-Analog Hybrid System-on-Chip for Capacitive Sensor Measurement and Control. [PDF]

Sensors (Basel), 2021
Gao Z, Zhou B, Li X, Yang L, Wei Q, Zhang R. +5 more
europepmc +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source

Controlled Synthesis of Space–Time Modulated Metamaterial for Enhanced Nonreciprocity by Machine Learning

Advanced Intelligent Systems
Nonreciprocity plays a fundamental role in governing direction‐dependent asymmetric wave propagation. Previous approaches to nonreciprocity involve ferrite‐based devices with bulky systems. Herein, the controlled synthesis of a space–time modulation (STM)
Ngoc Hung Phi +3 more
doaj +1 more source

Enhancing cell characterization with microfluidics and AI: a comprehensive review of mechanical, electrical, and hybrid techniques

Biotechnology Reports
This paper examines recent advancements in cell characterization using microfluidic devices, emphasizing mechanical, electrical, and hybrid methodologies.
Marwan Taha +3 more
doaj +1 more source

A System-on-Chip Based Hybrid Neuromorphic Compute Node Architecture for Reproducible Hyper-Real-Time Simulations of Spiking Neural Networks. [PDF]

Front Neuroinform, 2022
Trensch G, Morrison A.
europepmc +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source

Enhanced microfluidic multi-target separation by positive and negative magnetophoresis

Scientific Reports
We introduce magnetophoresis-based microfluidics for sorting biological targets using positive Magnetophoresis (pM) for magnetically labeled particles and negative Magnetophoresis (nM) for label-free particles.
Saud Khashan +4 more
doaj +1 more source

Low Complexity System on Chip Design to Acquire Signals from MOS Gas Sensor Applications. [PDF]

Sensors (Basel), 2021
Talens JB, Pelegri-Sebastia J, Canet MJ.
europepmc +1 more source

medicine
memristor
in-memory computing

fpga
successive approximation register
deep neural network

analog-to-digital converter
machine learning