Results 231 to 240 of about 1,848,190 (310)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

How new quality productivity drives china's sustainable development: Evidence from dynamic indicator evolution. [PDF]

PLoS One
Lu M.
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Research on the spatial-temporal evolution of healthcare resource allocation efficiency in China. [PDF]

Front Public Health
Wan L, Ye J, Shi W, Huang Y, Huang S.
europepmc   +1 more source

Parasitic Plant–Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies

Advanced Science, EarlyView.
Parasitic plants devastate global agriculture through sophisticated molecular interactions with host crops. This review synthesizes current understanding of parasitic plant‐host interactions, from strigolactone‐mediated germination and haustorium formation to host defense mechanisms.
Jiayang Shi, Qi Xie, Feifei Yu
wiley   +1 more source

Development of novel DALY-based indices for assessing productivity loss and resource allocation for liver cancer in the MENA region. [PDF]

Popul Health Metr
Momahhed SS, Banaee A, Haghighathoseini A, Zendehdel A.   +3 more
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Nitrogen Fertilisation Modulates Photosynthetic Performance and Antioxidant Defence Mechanisms in Intercropped Cactus Under Semi-Arid Conditions. [PDF]

Plants (Basel)
Martins LDCS, Jardim AMDRF, Santos WMD, Morais JEF, Souza LSB, Silva LRLE, Souza PPS, Santos ARMD, Santos WRD, Alves CP, Silva EFD, Santos HRB, Souza CAA, Cruz Neto JFD, Simões AN, Ferreira-Silva SL, Wang J, Tang X, de Lima JLMP, Silva TGFD.   +19 more
europepmc   +1 more source

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

Advanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł, Michał Pruchniewski, Daniel Rybak, Piotr Jenczyk, Karolina Zakrzewska, Magdalena Bartolewska, Sławomir Błoński, Paweł Nakielski, Filippo Pierini   +8 more
wiley   +1 more source

Soil microbial community differences drive variation in Pinus sylvestris physiology, productivity, and responses to elevated CO₂. [PDF]

Environ Microbiome
Anthony MA, Röckel N, Traistaru A, Krishna A, Meesenburg H, Wagner M, Jacob F, Gessler A, Waldner P, Schaub M, Ferretti M, Schmitz A, van den Bulk P, Hensen A, Hupperts SF, Bialic-Murphy L, Averill C.   +16 more
europepmc   +1 more source