Results 241 to 250 of about 1,848,190 (310)

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Dairy farming and climate parameters: an analysis of high productivity milk-producing cities in Minas Gerais, the leading dairy state in Brazil. [PDF]

Braz J Vet Med
Dias-Souza MV, Oliveira GAB, Martins AB.
europepmc   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Carbonate burial regimes, the Meso-Cenozoic climate, and nannoplankton expansion. [PDF]

Proc Natl Acad Sci U S A
Salles T, Husson L, Trung Nguyen T, Vila-Concejo A, Leonard J, Da Silva AP, Webster JM, Giraud F.   +7 more
europepmc   +1 more source

Nanozymes for Energy and Environmental Sustainability

Advanced Science, EarlyView.
At present, the widely used nanozymes are oxidoreductase and hydrolase, which have proved to have great application prospects in energy and environment. ABSTRACT Nanozymes have shown remarkable promise in addressing pressing challenges in energy and environmental sustainability.
Xiaoqi Li, Jinxing Chen, Shaojun Dong
wiley   +1 more source

Decoupled Antarctic and Subarctic export productivity under intensified Southern Hemisphere westerlies during the last interglacial. [PDF]

Nat Commun
Lu L, Yang Q, Gutjahr M, Shi Q, Wu R, Huang H, Luo Y, Yang H, Song Z, Jiping L, Kao SJ.   +10 more
europepmc   +1 more source

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

Advanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv, Pengshuai Yan, Huan Chen, Guangxian Li, Yiyue Zhao, Yanhui Chen, Wen‐Xue Li, Qingguo Du   +7 more
wiley   +1 more source

Effect of porous material and black coating on solar desalination for sustainable water harvesting: A thermo-exergo-economic and environmental analysis. [PDF]

Sci Rep
Sharma N, Kumar A, Cep R, Monika, Katiyar A.   +4 more
europepmc   +1 more source

Phosphorus fertilization and maize intercropping with peanut synergistically reshape rhizosphere microbiome and enhance crop yield. [PDF]

Front Microbiol
Zheng Y, Zhao W, Hu X, Li Z, Gao K, Jiao N.   +5 more
europepmc   +1 more source

National and State Societal Costs of Schizophrenia in the US in 2024.

JAMA Psychiatry
Krasa HB, Baumgardner JR, Brewer IP, Chou JW, Flottemesch T, Markowitz JT, Williams C, Nagendra A.   +7 more
europepmc   +1 more source