Results 51 to 60 of about 18,382,058 (316)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Public safety mobile broadband: draft report [PDF]

open access: yes, 2015
The draft report was released on 23 September 2015. You are invited to examine the report and to make written submissions by Wednesday 28 October 2015. This draft report looks at the best way to deliver a Public Safety Mobile Broadband (PSMB) capability
Productivity Commission
core  

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand   +5 more
wiley   +1 more source

A new species of Arachis (Fabaceae) from Mato Grosso, Brazil, related to A. matiensis

open access: yesBonplandia, 2017
In the original description of Arachis matiensis, two isolated populations, from the municipality of Cáceres, Mato Grosso State, Brazil, were listed as possibly representing a different species, but the analysis of additional materials, and further ...
José F. M. Valls, Charles E. Simpson
doaj   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

open access: yesArthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo   +6 more
wiley   +1 more source

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

open access: yesArthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo   +4 more
wiley   +1 more source

Boosting productivity in the services sector: 2nd interim report - competition and ICT topics [PDF]

open access: yes, 2014
Contains questions, findings and recommendations important to raising services-sector productivity in New Zealand, focusing on the adoption of information and communications technology by service firms.

core  

Assessing cropping systems and mustard varieties for enhanced system yield and profitability: strategies for climate resilience in arid Western Rajasthan

open access: yesFrontiers in Sustainable Food Systems
ContextMustard (Brassica juncea L.) is a major oilseed crop in India, particularly suited to arid and semi-arid regions like Rajasthan, where low soil fertility, erratic rainfall, and limited irrigation resources constrain productivity.
Madan Lal Reager   +10 more
doaj   +1 more source

Investigating difficulties and challenges of university administrators in developing academic branches and increasing research quality and productivity at industrial and non industrial universities(a qualitative study)

open access: yesآموزش مهندسی ایران, 2011
Globalization and knowledge-oriented economic development have brought about basic changes in the structure and responsibilities of higher education all over the world.
Mohammad hassan Pardakhtchi   +2 more
doaj   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

open access: yesAdvanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares   +3 more
wiley   +1 more source

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