Results 71 to 80 of about 3,166,293 (279)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Free field Active Noise Control system development using a 3D Finite Element based approach

Acta Acustica
This technical article presents a systematic methodology for efficient design, modeling, and validation of an Active Noise Control (ANC) system under free field conditions, aiming for global noise reduction.
Budnik Maximilian, Mees Valentin
doaj   +1 more source

Adaptive Piezoelectric Absorber for Active Vibration Control

Actuators, 2016
Passive vibration control solutions are often limited to working reliably at one design point. Especially applied to lightweight structures, which tend to have unwanted vibration, active vibration control approaches can outperform passive solutions.
Sven Herold, Dirk Mayer
doaj   +1 more source

Maximizing Service Reliability in Distributed Computing Systems with Random Node Failures: Theory and Implementation [PDF]

, 2010
In distributed computing systems (DCSs) where server nodes can fail permanently with nonzero probability, the system performance can be assessed by means of the service reliability, defined as the probability of serving all the tasks queued in the DCS ...
Dhakal, Sagar, Hayat, Majeed M., Pezoa, Jorge E.   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Development and Implementation of a Multi-Channel Active Control System for the Reduction of Road Induced Vehicle Interior Noise

Actuators, 2018
An optimized driving comfort with a low interior noise level is an important intention in the passenger car development process. The interior noise level caused by the dynamic interaction between the rolling tyre and the rough road surface and ...
Gunnar Gäbel, Jonathan Millitzer, Heiko Atzrodt, Sven Herold, Andreas Mohr   +4 more
doaj   +1 more source

Reliability analysis of distribution network [PDF]

, 2014
The knowledge of the reliability of distribution networks and systems is important consideration in the system planning and operations for development and improvements of power distribution systems. To achieve the target as minimum interruptions as
Anthony, Roystone
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Crack Propagation Calculations for Optical Fibers under Static Bending and Tensile Loads Using Continuum Damage Mechanics

Sensors, 2017
Static fatigue behavior is the main failure mode of optical fibers applied in sensors. In this paper, a computational framework based on continuum damage mechanics (CDM) is presented to calculate the crack propagation process and failure time of optical ...
Yunxia Chen, Yuxuan Cui, Wenjun Gong
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source