Results 121 to 130 of about 21,648,517 (282)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Usability Analysis of the Sahabatku Application using the System Usability Scale
International Journal Science and TechnologyAfter COVID-19, various mental health issues have been increasing. This is where the important role of information technology comes in, one of which is in the implementation of counseling, which has shifted from face-to-face to online. The Sahabatku application is one of the psychological counseling applications created as an effort to improve mental ...
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Usability in learning management systems: A mixed-method analysis
International Journal of Pioneering Technology and EngineeringUsability analysis in software has a critical role in creating useful products for users and obtaining the necessary feedback. Learning Management Systems (LMSs) are among the most frequently used software in distance education.
Pembe Pelin Koca, Hakan Özcan
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Conception and Implementation of a Usability Problem Analysis Tool and its Comparison with another Usability Technique on the Example of a Workflow-driven Integration Environment [PDF]
, 2013 The demand for good usability has become indisputable as usable products are more profitable, secure and enhance the reputation of its producing company. For many applications abstract usability problems like "Users have problems using the online shop"
Seebach, Oliver
core
Evaluation of Travel App’s Usability Using the System Usability Scale Method
Scientific Journal of InformaticsPurpose: The objective of this study is to assess the usability of the Baraya Travel application, highlighting areas for enhancement to improve the online ticket booking experience for users. By concentrating on the Baraya Travel app as the research subject, the study intends to offer valuable insights for its developers.
Revi Raka Putra +2 more
openaire +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Journal of Applied Informatics and ComputingIn the digital era, technology has transformed the travel and tourism industry, with Online Travel Agents (OTAs) like Traveloka, Tiket.com, and Agoda offering convenient trip planning through digital platforms.
Ayunda Larasati, Tranggono Tranggono
doaj +1 more source