Results 131 to 140 of about 314,793 (282)

PEMBUATAN TOOLS ANALISIS SPASIAL KEKRITISAN LAHAN MENGGUNAKAN MODELBUILDER ARCGIS [PDF]

, 2018
Jumlah lahan kritis di Indonesia terus mengalami peningkatan, sehingga diperlukan kegiatan rehabilitasi dan perbaikan DAS. Kegiatan rehabilitasi membutuhkan informasi mengenai tingkat kekritisan lahan pada suatu daerah agar memudahkan kegiatan tersebut ...
Nurul Akmal
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Analisis Usability Aplikasi LegoBoost Builder Dengan Metode System Usability Scale

TeIKa
Penelitian ini dilakukan untuk menilai dan menganalisis tingkat kebergunaan (usability) aplikasi LegoBoost Builder dengan memanfaatkan metode System Usability Scale (SUS). Aplikasi LegoBoost Builder adalah produk yang dikembangkan secara internal oleh Lego Corporation.
Yestrada Henanda, Eka Wahyu Hidayat, Aldy Putra Aldya   +2 more
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Usability Analysis of Online Travel Agent Applications Using System Usability Scale and Electroencephalography

Journal of Applied Informatics and Computing
In the digital era, technology has transformed the travel and tourism industry, with Online Travel Agents (OTAs) like Traveloka, Tiket.com, and Agoda offering convenient trip planning through digital platforms.
Ayunda Larasati, Tranggono Tranggono
doaj   +1 more source

PAON usability testing using system usability scale

Journal of Physics: Conference Series, 2019
K Setemen, L J Erawati Dewi, I K Purnamawan   +2 more
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Usability of the GrabMerchant Application: An Evaluation using the System Usability Scale and the Retrospective Think Aloud Method

Sistemasi: Jurnal Sistem Informasi
GrabMerchant is an application used by GrabFood and GrabMart business partners to manage various business operations, including order processing, inventory management, and promotional activities.
Rima Handayani, Evi Maria
doaj   +1 more source