Results 151 to 160 of about 12,410 (294)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

ANALISIS USABILITY PADA GAME MOBILE GROWTOPIA MENGGUNAKAN METODE SYSTEM USABILITY SCALE (SUS)

Growtopia adalah salah satu game sandbox multipemain yang memiliki komunitas yang besar dan terus berkembang. Game ini menawarkan berbagai fitur seperti perdagangan, pembangunan dunia, dan interaksi sosial yang luas.
Simanjuntak, Sahat Maruli, Putra, I Nyoman Tri Anindia   +1 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Analysis of the Usability of the Badkidstore Indonesia Website Using the System Usability Scale (SUS) Method

Proceeding International Conference on Digital Education and Social Science
The development of e-commerce in Indonesia requires business actors to provide websites that not only function as a marketing medium, but are also able to provide a good user experience. The Badkidstore Indonesia website is an e-commerce platform that sells casual wear fashion products for young soccer players.
null Achmadhin Tristan Syafaat, null Sucipto, null Muhammad Najibulloh Muzaki   +2 more
openaire   +1 more source

ANALISIS USABILITY PADA SISTEM INFORMASI AKADEMIK MAHASISWA UNIVERSITAS MUHAMMADIYAH RIAU MENGGUNAKAN METODE SYSTEM USABILITY SCALE (SUS) [PDF]

, 2019
ABSTRAK Sistem informasi akademik merupakan media yang dapat membantu proses berjalannya kegiatan akademik. Kelancaran proses akademik dipengaruhi oleh kualitas sistem informasi yang dimiliki.
Widad Ulfika Sari, -
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Monitoring Upper Extremity Function of Individuals With Breast Cancer: Development and Usability of the mHealth System

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Upper extremity (UE) impairment is a leading cause of decreased function in breast cancer (BC) survivors. Failure to recognize and properly manage these impairments can lead to significant and sustained functional limitations.
Jenna Smith-Turchyn PT, PhD, Jordon L. Hvizd MSc, Edward R. Sykes PhD, Som D. Mukherjee MD, FRCP(C), Tara Packham OT, PhD, Margaret L. McNeely PT, PhD, Carolyn Moorlag PhD, Ethan Shen PhD, Haruna Isah PhD, Christopher Anand PhD, Julie Richardson PT, PhD   +10 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

ANALISIS USABILITY PADA APLIKASI UNSIKA CONNECT MENGGUNAKAN METODE SYSTEM USABILITY SCALE (SUS)

Jurnal Informatika dan Teknik Elektro Terapan
Pengujian usability merupakan hal penting untuk mengukur kepuasan pengguna terhadap suatu sistem atau aplikasi. Penelitian ini menggunakan metode System Usability Scale (SUS) untuk mengevaluasi tingkat kepuasan pengguna pada aplikasi Unsika Connect, sebuah aplikasi mobile yang dikembangkan oleh PT Sukacode Solusi Teknologi sebagai platform komunikasi ...
openaire   +2 more sources