Results 201 to 210 of about 3,508,348 (267)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Prevalence of hyperuricemia among patients with non-communicable diseases in Ethiopia: a systematic review and meta-analysis. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Habtamu A, Mulatie Z, Achame MS, Desale S, Sebsibe S, Erkihun Y, Kassa Y, Gessese T, Alebachew M, Feyisa MS, Eshetu B.   +10 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Designing and conducting systematic reviews and meta-analyses in ophthalmology. [PDF]

Med Hypothesis Discov Innov Ophthalmol
Keshtkar A, Ghasemi M.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Factors associated with depression among people with cancer: Systematic umbrella review. [PDF]

Palliat Support Care
Zaccagnino B, Bettella A, Olivetti AF, Cavalieri D'Oro V, Cruciata M, Tarricone A, Iorio C, Sancassiani F, Kalcev G, Atzeni M, Vacca V, Perra A, Monni M, Muscettola A, Nanni MG, Caruso R, Grassi L, Belvederi Murri M.   +17 more
europepmc   +1 more source

Evaluating the Utility of Artificial Intelligence in Conducting Systematic Reviews. [PDF]

Arthroplast Today
Carrier R, Lopez L, Moya A, Hernandez VH, D'Apuzzo MR, McNamara CA.   +5 more
europepmc   +1 more source

The Role of Virtual and Augmented Reality in Transsphenoidal Surgical Approaches to the Sellar and Parasellar Area-A Systematic Review. [PDF]

J Clin Med
Bechev K, Markov D, Aleksiev V, Markov G, Poryazova E, Fasova A.   +5 more
europepmc   +1 more source

Correction to: Mapping the brain's fatigue network: a transdiagnostic systematic review and meta-analysis on functional correlates of mental fatigue. [PDF]

Brain Commun
europepmc   +1 more source

Experiences from conducting systematic reviews of systematic reviews. [PDF]

BMC Med Res Methodol
Grooten WJA, Bohman T, Bostrom C, Dedering Å, Halvorsen M, Kuster RP, Nilsson-Wikmar L, Olsson CB, Rovner G, Tseli E, Rasmussen-Barr E.   +10 more
europepmc   +1 more source