Results 101 to 110 of about 1,888,501 (343)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Identifying studies evaluating susceptibility factors for chemical health assessments: A case study focused on methylmercury developmental neurotoxicity

Environment International
Identifying susceptibility factors for adverse health effects from chemical exposures is an important aspect of characterizing human health impacts. However, to date, an efficient approach for identifying these factors has not been established.
Deborah Segal, Rebecca Nachman, Onyemaechi Nweke, Elizabeth Radke, Geanine Brunson, Bita Khoshhal, G. Nicole Helguero, Leonid Kopylev   +7 more
doaj   +1 more source

Information sources for obesity prevention policy research: a review of systematic reviews

Systematic Reviews, 2017
Background Systematic identification of evidence in health policy can be time-consuming and challenging. This study examines three questions pertaining to systematic reviews on obesity prevention policy, in order to identify the most efficient search ...
Rosie Hanneke, Sabrina K. Young
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Meta-analysis and systematic review of skin graft donor-site dressings with future guidelines. [PDF]

, 2018
Background: Many types of split-thickness skin graft (STSG) donor-site dressings are available with little consensus from the literature on the optimal dressing type. The purpose of this systematic review was to analyze the most recent outcomes regarding
Alwaal, Assadian, Baser, Begg, Blount, Brown, Brölmann, Cheesborough, Chung, Cigna, Demirtas, Dickersin, Druery, Fearmonti, Feldman, Fernandes de Carvalho, Ferreira, Ghieh, Goertz, Haith, Hasatsri, Hassanpour, Healy, Iwuagwu, Jadad, Junker, Kaiser, Konieczynska, Konieczynska, Konieczynska, Lairet, Liu, Lohsiriwat, Massand, McCartan, Metelmann, Moher, Muangman, Petruzzelli, Polfer, Potocká, Quinn, Rakel, Ratner, Salehi, Selig, Serino, Singh, Siritientong, Soltan Dallal, Tan, Tanaka, Vaghardoost, Vejdan, Villa-Camacho, Voineskos, Wiechula, Wisely, Zidan   +58 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Systematic review and quality analysis of emerging diagnostic measures for calcium pyrophosphate crystal deposition disease. [PDF]

, 2016
ObjectivesCalcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR ...
Chen, K, Terkeltaub, R, Wu, Y
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Literature Searches Report in Systematic Reviews

Revista Española de Enfermedades Digestivas
In response to the study by Tian et al. on the immunogenicity of COVID-19 vaccines in patients with autoimmune hepatitis, this letter commends the authors' contribution but highlights a critical omission: the lack of details regarding their search strategy. Reproducibility, as defined by the National Academies of Sciences, Engineering, and Medicine, is
openaire   +2 more sources