Results 81 to 90 of about 1,921,675 (302)

A Plea for Minimally Biased Empirical Philosophy [PDF]

, 2017
Naturalistic philosophers rely on literature search and review in a number of ways and for different purposes. Yet this article shows how processes of literature search and review are likely to be affected by widespread and systematic biases.
Polonioli, Andrea
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Acute type A aortic dissection in patients with non-prior cardiac surgery vs. prior cardiac surgery: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine
BackgroundPatients with prior cardiac surgery undergoing acute type A aortic dissection (ATAAD) are thought to have worse clinical outcomes as compared to the patients without prior cardiac surgery.AimTo compare the safety and efficacy of ATAAD in ...
Muhammad Ahmed, Hafsah Alim Ur Rahman, Muhammad Ahmed Ali Fahim, Zahabia Altaf Hussain, Nisar Ahmed, Muhammad Sohaib Asghar   +5 more
doaj   +1 more source

Literature searching for social science systematic reviews: consideration of a range of search techniques [PDF]

Health Information & Libraries Journal, 2010
AbstractBackground:  Literature for a systematic review on the student experience of e‐learning is located across a range of subject areas including health, education, social science, library and information science.Objectives:  To assess the merits and shortcomings of using different search techniques in retrieval of evidence in the social science ...
Diana, Papaioannou, Anthea, Sutton, Christopher, Carroll, Andrew, Booth, Ruth, Wong   +4 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Bubble effect: including internet search engines in systematic reviews introduces selection bias and impedes scientific reproducibility

BMC Medical Research Methodology, 2018
Background Using internet search engines (such as Google search) in systematic literature reviews is increasingly becoming a ubiquitous part of search methodology.
Marko Ćurković, Andro Košec
doaj   +1 more source

Practical residue curve map analysis applied to solvent recovery in non-ideal binary mixtures by batch distillation processes [PDF]

, 2006
Batch distillation inherent advantages has initiated recent search for process feasibility rules enabling the separation of azeotropic or difficult zeotropic binary mixtures thanks to the addition of an entrainer.
Baudouin Olivier, Castelain Pierre, Doherty, Doherty, Doherty, Gmehling, Joulia Xavier, Kiva, Lang, Lelkes, Lelkes, Modla, Mujtaba, Rodriguez-Donis, Rodriguez-Donis, Rodriguez-Donis, Rodriguez-Donis Ivonne, Rodríguez-Donis, Rosemain Olivier, Seider, Skouras, Skouras, Stichlmair, Thery, Vacher Alain, Vincent Gerbaud, Widagdo   +26 more
core   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Type and Timing of Rehabilitation Following Acute and Subacute Spinal Cord Injury: A Systematic Review [PDF]

, 2017
Objectives: The objective of this study was to conduct a systematic review of the literature to address the following clinical questions: In adult patients with acute and subacute complete or incomplete traumatic SCI, (1) does the time interval between ...
Burns, Anthony S., Dettori, Joseph R., Fehlings, Michael G., Kalsi-Ryan, Sukhvinder, Marino, Ralph J., Middleton, James W., Mihalovich, Kathryn E., Tetreault, Lindsay A.   +7 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source