Results 61 to 70 of about 498,912 (261)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Acute type A aortic dissection in patients with non-prior cardiac surgery vs. prior cardiac surgery: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine
BackgroundPatients with prior cardiac surgery undergoing acute type A aortic dissection (ATAAD) are thought to have worse clinical outcomes as compared to the patients without prior cardiac surgery.AimTo compare the safety and efficacy of ATAAD in ...
Muhammad Ahmed, Hafsah Alim Ur Rahman, Muhammad Ahmed Ali Fahim, Zahabia Altaf Hussain, Nisar Ahmed, Muhammad Sohaib Asghar   +5 more
doaj   +1 more source

Automatic Boolean Query Formulation for Systematic Review Literature Search

Proceedings of The Web Conference 2020, 2020
Formulating Boolean queries for systematic review literature search is a challenging task. Commonly, queries are formulated by information specialists using the protocol specified in the review and interactions with the research team. Information specialists have in-depth experience on how to formulate queries in this domain, but may not have in-depth ...
Harrisen Scells, Guido Zuccon, Bevan Koopman, Justin Clark   +3 more
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Bubble effect: including internet search engines in systematic reviews introduces selection bias and impedes scientific reproducibility

BMC Medical Research Methodology, 2018
Background Using internet search engines (such as Google search) in systematic literature reviews is increasingly becoming a ubiquitous part of search methodology.
Marko Ćurković, Andro Košec
doaj   +1 more source

Literature searching for social science systematic reviews: consideration of a range of search techniques [PDF]

Health Information & Libraries Journal, 2010
AbstractBackground:  Literature for a systematic review on the student experience of e‐learning is located across a range of subject areas including health, education, social science, library and information science.Objectives:  To assess the merits and shortcomings of using different search techniques in retrieval of evidence in the social science ...
Diana, Papaioannou, Anthea, Sutton, Christopher, Carroll, Andrew, Booth, Ruth, Wong   +4 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Literature Searches Report in Systematic Reviews

Revista Española de Enfermedades Digestivas
In response to the study by Tian et al. on the immunogenicity of COVID-19 vaccines in patients with autoimmune hepatitis, this letter commends the authors' contribution but highlights a critical omission: the lack of details regarding their search strategy. Reproducibility, as defined by the National Academies of Sciences, Engineering, and Medicine, is
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source