Results 101 to 110 of about 11,023,121 (305)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The impact of patient, intervention, comparison, outcome (PICO) as a search strategy tool on literature search quality: a systematic review

Journal of the Medical Library Association, 2018
Objective: This review aimed to determine if the use of the patient, intervention, comparison, outcome (PICO) model as a search strategy tool affects the quality of a literature search.
Mette Brandt Eriksen, Tove Faber Frandsen   +1 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Flow diagram of literature search for systematic review.

, 2013
Flow diagram of literature search for systematic review.
Jonathan B. Angel (256485), Cecilia T. Costiniuk (337154), Dean A. Fergusson (169349), Steve Doucette (215693)   +3 more
core   +1 more source

Employee motivation in current literature: a systematic search

Entrepreneurship and Sustainability Issues
The main objective of this article is to systematise approaches to motivation in current professional literature and identify key factors influencing employee motivation, thereby contributing to both theoretical understanding and practical improvement of
Iveta Kmecová, Kateřina Jíchová
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Flow diagram of literature search for systematic review.

, 2016
Flow diagram of literature search for systematic review.
Sharon Walmsley (226609), Jonathan B. Angel (256485), M. John Gill (341799), Jean van Wyk (2152738), Pedro Cahn (4922), Jean-Guy Baril (641167), Joseph Gathe (2152735)   +6 more
core   +1 more source

Literature search strategy used in this systematic review and meta-analysis.

, 2023
Literature search strategy used in this systematic review and meta-analysis.
Easter Protiva Gain (15447647), M. Mahbub Hossain (14636753), Kazi Faria Islam (15447644), Hoimonty Mazumder (14636759), Farzana Rahman (4221163), Md Monir Hossain Shimul (15447656), Jyoti Das (3694576), Nobonita Saha (15447650), Irfath Sharmin Eva (15447653)   +8 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

PRISMA flow diagram of the systematic literature search.

, 2018
PRISMA flow diagram of the systematic literature search.
Laura Inhestern (2825246), Mona Leandra Peikert (5122244), Corinna Bergelt (2825249)   +2 more
core   +1 more source