Results 111 to 120 of about 1,849,194 (343)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Meta-analysis and systematic review of skin graft donor-site dressings with future guidelines. [PDF]

, 2018
Background: Many types of split-thickness skin graft (STSG) donor-site dressings are available with little consensus from the literature on the optimal dressing type. The purpose of this systematic review was to analyze the most recent outcomes regarding
Alwaal, Assadian, Baser, Begg, Blount, Brown, Brölmann, Cheesborough, Chung, Cigna, Demirtas, Dickersin, Druery, Fearmonti, Feldman, Fernandes de Carvalho, Ferreira, Ghieh, Goertz, Haith, Hasatsri, Hassanpour, Healy, Iwuagwu, Jadad, Junker, Kaiser, Konieczynska, Konieczynska, Konieczynska, Lairet, Liu, Lohsiriwat, Massand, McCartan, Metelmann, Moher, Muangman, Petruzzelli, Polfer, Potocká, Quinn, Rakel, Ratner, Salehi, Selig, Serino, Singh, Siritientong, Soltan Dallal, Tan, Tanaka, Vaghardoost, Vejdan, Villa-Camacho, Voineskos, Wiechula, Wisely, Zidan   +58 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

PRM32 Consistency In Search Strategies For Systematic Literature Reviews In Nice Submissions [PDF]

, 2003
L'edifici fou construït l'any 1880, aproximadament.Primer pla d'edifici plurifamiliar entre mitgeres i formant cantonada. Consta de planta baixa, entresòl, quatre plantes pis, planta terrat i unes remuntes, algunes d¿elles probablement posteriors ...
Murphy, D, Guy, H, Hirst, A
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Optimal search strategies for identifying sound clinical prediction studies in EMBASE [PDF]

, 2005
BACKGROUND: Clinical prediction guides assist clinicians by pointing to specific elements of the patient's clinical presentation that should be considered when forming a diagnosis, prognosis or judgment regarding treatment outcome.
A Laupacis, AG Randolph, AR Jadad, BJ Ingui, BT Walsh, CE Adams, FA McAlister, Jennifer L Holland, JF Steiner, JH Wasson, JI Emparanza, JW Ely, LM Bachmann, LM Bachmann, Nancy L Wilczynski, NL Wilczynski, NL Wilczynski, NL Wilczynski, PS Wells, R Brian Haynes, RB Haynes, RB Haynes, RJ Watson, SS Wong, T McGinn, TG McGinn   +25 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Risk of postoperative pulmonary complications in adult surgical patients with metabolic syndrome: a systematic review and meta-analysis protocol [PDF]

, 2019
Background: Metabolic syndrome (MetS) is defined as an accumulation of risk factors that include chronic hypertension, dyslipidaemia, insulin resistance and obesity and leads to an increased risk for diabetes, cardiovascular disease and stroke.
Gow, Jeffrey, Norris, Philip, Ralph, Nicholas, Silvey, Natalie, Viljoen, Bianca   +4 more
core   +3 more sources

Literature Searches Report in Systematic Reviews

Revista Española de Enfermedades Digestivas
In response to the study by Tian et al. on the immunogenicity of COVID-19 vaccines in patients with autoimmune hepatitis, this letter commends the authors' contribution but highlights a critical omission: the lack of details regarding their search strategy. Reproducibility, as defined by the National Academies of Sciences, Engineering, and Medicine, is
openaire   +2 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source