Results 91 to 100 of about 6,173,935 (359)

Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis

Critical Care, 2018
Background Arterial hyperoxia may induce vasoconstriction and reduce cardiac output, which is particularly undesirable in patients who already have compromised perfusion of vital organs.
Bob Smit, Yvo M. Smulders, Etto C. Eringa, Heleen M. Oudemans - van Straaten, Armand R. J. Girbes, Kimberley E. Wever, Carlijn R. Hooijmans, Angelique M. E. Spoelstra - de Man   +7 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

A scientometric analysis of research trends, visualization, and emerging patterns in canine olfactory detection for cancer [PDF]

Veterinary World
Background and Aim: Dogs can detect specific cancer odors with their exceptional sense of smell. This study aimed to conduct a scientometric analysis of canine olfactory detection in oncology, identifying trends, visualizations, and patterns ...
Fran Espinoza-Carhuancho, Franco Mauricio, Cesar Mauricio-Vilchez, Diego Galarza-Valencia, Julia Medina, Josmel Pacheco-Mendoza, Frank Mayta-Tovalino   +6 more
doaj   +1 more source

Interventions for physician burnout: A systematic review of systematic reviews

International Journal of Preventive Medicine, 2018
Occupational burnout is a common syndrome among physicians, and several individual-directed and organization-directed interventions have been implemented to reduce it. Until now, several review studies have tried to identify and introduce the most appropriate interventions.
Simin dokht Kalani, Peyman Adibi, Parviz Azadfallah, Hamidreza Oreyzi   +3 more
openaire   +4 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

A model six-month workshop for developing systematic review protocols at teaching hospitals: action research and scholarly productivity

BMC Medical Education, 2021
Background Research engagement contributes to the improvement of patient care. A systematic review is a suitable first scholarly activity because it entails summarization of publicly available data and usually requires neither rigorous ethical review nor
Hiraku Tsujimoto, Yuki Kataoka, Yukihito Sato, Masahiro Banno, Emi Tsujino-Tsujimoto, Yukiyoshi Sumi, Ryuichi Sada, Takashi Fujiwara, Yoichi Ohtake, Junji Kumasawa, Haruki Imura, Yoshinobu Matsuda, Ryuhei So, Tomoko Kagawa, Takashi Yoshioka, Yu Uneno, Hiroyuki Nagano, Mai Akazawa, Takunori Hozumi, Yasushi Tsujimoto   +19 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Medicinal Plants Used in Treatment of Noninfectious Skin Diseases: A Systematic Review

Journal of Medicinal Plants, 2012
The use of medicinal plants and plant active constituents in the treatment of skin diseases is very common. Here, primarily the clinical trials concerning the use of medicinal plants and plant active constituents in the treatment of noninfectious skin ...
S Kianbakht
doaj  

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Evaluating methodological quality of Prognostic models Including Patient-reported HeAlth outcomes in oncologY (EPIPHANY): A systematic review protocol [PDF]

, 2018
Introduction While there is mounting evidence of the independent prognostic value of patient-reported outcomes (PROs) for overall survival (OS) in patients with cancer, it is known that the conduct of these studies may hold a number of methodological ...
Anota, Amélie, Collins, Gary S., Cottone, Francesco, Deliu, Nina, Efficace, Fabio   +4 more
core   +2 more sources