Results 101 to 110 of about 6,312,461 (358)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Harm reduction among injecting drug users - evidence of effectiveness [PDF]

, 2010
This chapter synthesises and evaluates the available direct evidence relating to the impact of needle and syringe programmes (NSPs), opioid substitution treatment (OST), drug consumption rooms (DCRs), and peer naloxone distribution (PND) on HIV/hepatitis
Goldberg, David, Hickman, Matthew, Hutchinson, Sharon, Kimber, Jo, Palmateer, Norah, Rhodes, Tim   +5 more
core   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Amblyopia and quality of life: a systematic review [PDF]

, 2010
Background/Aims Amblyopia is a common condition which can affect up to 5% of the general population. The health-related quality of life (HRQoL) implications of amblyopia and/or its treatment have been explored in the literature.
A Göransson, A Searle, A Searle, AL Webber, AL Webber, B Chua, C Leach, C Schmucker, C Schmucker, C Williams, D Newsham, D Newsham, D Satterfield, DE Stull, E Kaltenthaler, E Stifter, EA Packwood, EE Birch, EP Steinberg, ES van de Graaf, ES van de Graaf, ES van de Graaf, HW Marsh, J Brazier, J Carlton, J Carlton, J Felius, J Felius, J Horwood, JM Holmes, JM Holmes, JS Rahi, JW Varni, JW Varni, K Koklanis, K Sabri, L Dias, L Dias, LC Parkes, M Dixon-Woods, M Schumacher, M Vianya-Estopa, MJ Christie, MK Margolis, MS Lewis-Jones, Pediatric Eye Disease Investigator Group, RP Rutstein, S Hrisos, S Jackson, SA Clarke, SE Loudon, SE Loudon, SR Cole, YF Choong   +53 more
core   +6 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Psychoeducational interventions in adolescent depression: A systematic review [PDF]

, 2017
Background: Adolescent depression is common and leads to distress and impairment for individuals/families. Treatment/prevention guidelines stress the need for good information and evidence-based psychosocial interventions.
Bevan Jones, Rhys, Jones, Ian, Simpson, Sharon, Smith, Daniel, Stone, Zoe, Thapar, Ajay, Thapar, Anita   +6 more
core   +3 more sources

Why emerging leaders should focus on being good postdoctoral supervisors

FEBS Letters, EarlyView.
Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski, Clara Oudenaarden, Miao Tian, Diyavarshini Gopaul, Anita Kurilla, Pelin Gülizar Ersan   +5 more
wiley   +1 more source

Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis

Nutrition Journal
Background Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption
Eunice Mah, Cassi N. Uffelman, Traci M. Blonquist, Ding Ding Wang, Colin D. Rehm, Shellen R. Goltz, YiFang Chu   +6 more
doaj   +1 more source

Systematic review of antimicrobial drug prescribing in hospitals. [PDF]

, 2006
Prudent antibiotic prescribing to hospital inpatients has the potential to reduce the incidences of antimicrobial resistance and healthcare-associated infection.
Brown, E, Davey, P, Fenelon, L, Finch, R, Gould, I.M., Homes, A, Ramsay, Craig R, Taylor, E, Wiffen, P, Wilcox, M   +9 more
core   +3 more sources