Results 131 to 140 of about 15,576,784 (415)

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Search Strategy Formulation for Systematic Reviews: issues, challenges and opportunities [PDF]

arXiv, 2021
Systematic literature reviews play a vital role in identifying the best available evidence for health and social care policy. The resources required to produce systematic reviews can be significant, and a key to the success of any review is the search strategy used to identify relevant literature.
arxiv  

Concepts and forms of greenwashing: a systematic review

Environmental Sciences Europe, 2020
Background The aggravation of environmental problems has led companies to seek the development and commercialization of green products. Some companies mislead their stakeholders through a phenomenon called greenwashing. Results This paper aims to explore
Sebastião Vieira de Freitas Netto, M. Sobral, Ana Ribeiro, Gleibson Robert da Luz Soares   +3 more
semanticscholar   +1 more source

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

Systematic review of the effectiveness of standalone passive countermeasures on microgravity-induced physiologic deconditioning

npj Microgravity
A systematic review of literature was conducted to evaluate the effectiveness of passive countermeasures in ameliorating the cardiopulmonary and musculoskeletal effects of gravitational unloading on humans during spaceflight.
Syed Shozab Ahmed, Nandu Goswami, Adam Sirek, David Andrew Green, Andrew Winnard, Leonie Fiebig, Tobias Weber   +6 more
doaj   +1 more source

Drug delivery systems for ovarian cancer treatment: a systematic review and meta-analysis of animal studies [PDF]

PeerJ, 2015
Current ovarian cancer treatment involves chemotherapy that has serious limitations, such as rapid clearance, unfavorable biodistribution and severe side effects.
René Raavé, Rob B.M. de Vries, Leon F. Massuger, Toin H. van Kuppevelt, Willeke F. Daamen   +4 more
doaj   +2 more sources

Systematic literature review protocol. Learning-outcomes and teaching-learning process: a Bloom's taxonomy perspective [PDF]

arXiv, 2019
Context: The importance of defining learning outcomes and the planning stage for a systematic literature review. Objective: A protocol for carrying out a systematic literature review about the evidence for the tool support for the learning outcomes and the teaching-learning process using Bloom's taxonomy to address it.
arxiv  

NLPeer: A Unified Resource for the Computational Study of Peer Review [PDF]

arXiv, 2022
Peer review constitutes a core component of scholarly publishing; yet it demands substantial expertise and training, and is susceptible to errors and biases. Various applications of NLP for peer reviewing assistance aim to support reviewers in this complex process, but the lack of clearly licensed datasets and multi-domain corpora prevent the ...
arxiv  

Medical and Surgical Education Challenges and Innovations in the COVID-19 Era: A Systematic Review.

In Vivo, 2020
The aim of this systematic review was to identify the challenges imposed on medical and surgical education by the COVID-19 pandemic, and the proposed innovations enabling the continuation of medical student and resident training.
Aikaterini Dedeilia, Marinos G Sotiropoulos, J. Hanrahan, D. Janga, P. Dedeilias, M. Sideris   +5 more
semanticscholar   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source