Results 61 to 70 of about 5,992,310 (307)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Effectiveness of non-technical skills training in intensive care units: a systematic review

BMC Medical Education
Background Non-technical skills (NTS) are social, cognitive and psychological skills that are related to safety and efficiency in the healthcare process. These skills have an important role in the intensive care once are closely related to the occurrence
Isac Davidson Santiago Fernandes Pimenta, Ádala Nayana de Sousa Mata, Isaac Newton Machado Bezerra, Rícia Medeiros Palmeira de Araújo, Jorge Lucas Alves Santana, Helaine Carneiro Capucho, Adriana Catarina de Souza-Oliveira, Paloma Echevarría-Pérez, Daniel Guillén-Martínez, Grasiela Piuvezam   +9 more
doaj   +1 more source

Exploring the pharmacological versatility of ficus carica: Modulating classical immunometabolism and beyond

Pharmacological Research, 2023
The burden of metabolic disorders is alarmingly increasing globally. On the other hand, sustainability is the key project of the 21st century. Natural products offer a coherent option for the complementary management of both these challenges.
Amene Saghazadeh
doaj   +1 more source

A question of trust: can we build an evidence base to gain trust in systematic review automation technologies? [PDF]

, 2019
Background Although many aspects of systematic reviews use computational tools, systematic reviewers have been reluctant to adopt machine learning tools.
Gilbert, Stephen, Gilbert, Stephen, Glasziou, Paul, Hutton, Brian, O'Connor, Annette, O'Connor, Annette, Thomas, James, Tsafnat, Guy   +7 more
core   +5 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Scientometric mapping of the trends, impact, and thematic evolution of scientific production on ehrlichiosis in veterinary medicine [PDF]

Veterinary World
Background and Aim: This study focuses on the scientific output of ehrlichiosis, a tick-borne disease that affects a variety of animal species, including dogs, cats, and livestock.
Fran Espinoza-Carhuancho, Julia Medina, Cesar Mauricio-Vilchez, Diego Galarza-Valencia, Roman Mendoza, Josmel Pacheco-Mendoza, Frank Mayta-Tovalino   +6 more
doaj   +1 more source

The impact of eHealth on the quality and safety of health care : a systematic overview [PDF]

, 2010
There is considerable international interest in exploiting the potential of digital solutions to enhance the quality and safety of health care. Implementations of transformative eHealth technologies are underway globally, often at very considerable cost.
Anandan, Chantelle, Black, Ashly D., Bokun, Tomislav, Car, Josip, Cresswell, Kathrin, Djulbegovic, Benjamin, Majeed, Azeem, McKinstry, Brian, Pagliari, Claudia, Procter, Rob, Sheikh, Aziz   +10 more
core   +6 more sources

Apexification: A systematic review

Journal of Conservative Dentistry, 2018
Pulpal necrosis in permanent teeth that have not completed their root development leads to teeth with a very short root, roots with very thin walls, and an inadequate crown-root ratio, which overshadows their survival prognosis. Currently, there are various therapies to treat immature permanent teeth with pulpal pathology such as the case of ...
Guerrero, Fabricio, Mendoza Mendoza, María Asunción, Ribas Pérez, David, Aspiazu, Karla   +3 more
openaire   +5 more sources

A Systematic Review of Systematic Reviews of Spinal Manipulation [PDF]

Journal of the Royal Society of Medicine, 2006
Objectives To systematically collate and evaluate the evidence from recent systematic reviews of clinical trials of spinal manipulation. Design Literature searches were carried out in four electronic databases for all systematic reviews of the effectiveness of spinal manipulation in any indication, published between 2000 and May 2005.
E, Ernst, P H, Canter
openaire   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source