Results 91 to 100 of about 63,620,147 (200)

Leveraging the Opportunities of Mixed Methods in Systematic Review: Introduction to Systematic Mixed Studies Review

, 2021
The research community has increasingly recognized the value of synthesis studies in expanding our understanding of phenomena. Mixed-methodology broadly has also gained ground as a pragmatic approach to research investigations.
Ferguson, Sarah, Reid Kerrigan, Monica
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Associations between cannabis dispensary density and cannabis use behaviors and related harms: a systematic review protocol

, 2020
This systematic review protocol details planned actions of our review team. Document includes purpose, research question(s), inclusion and exclusion criteria, and planned methods for searching the literature, data extraction, and quality ...
Emily Jones, Dr. Pamela Trangenstein
core   +1 more source

A systematic literature review on the rural-urban well-being gap in Europe

Bio-based and Applied Economics, 2023
A large amount of policy support is spent to foster the development of rural areas in Europe. However, empirical evidence on the well-being differential between rural and urban areas in Europe is scant and incomplete.
Cesare Meloni, Benedetto Rocchi, Simone Severini   +2 more
doaj  

The relationship between organizational factors and residual risk in the mining industry – a protocol for updating a systematic review

International Journal of Occupational and Environment Safety, 2019
Organizational factors have long been suspected to have the greatest influence on individual and group behavior in the workplace, although there is little research on their influence in mining workplaces.
Wonder Nyoni, Manikam Pillay, Mark Rubin, Marcus C Jefferies   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Opiate Use Disorder and Exercise: A Systematic Review

, 2022
A Systematic Review was conducted on Opiate Use Disorder and Exercise to evaluate for gaps in knowledge on the ...
Mandato, Joe
core   +1 more source