Results 1 to 10 of about 1,367,492 (120)

Network meta-analysis of eribulin versus other chemotherapies used as second- or later-line treatment in locally advanced or metastatic breast cancer

BMC Cancer, 2021
Background Eribulin mesylate (ERI; Halaven®) is a microtubule inhibitor approved in the United States for metastatic breast cancer patients with at least two prior chemotherapy regimens for metastatic breast cancer, and in the European Union in locally ...
Qi Zhao, Rachel Hughes, Binod Neupane, Kristin Mickle, Yun Su, Isabelle Chabot, Marissa Betts, Ananth Kadambi   +7 more
doaj   +1 more source

Structured expert elicitation to inform long-term survival extrapolations using alternative parametric distributions: a case study of CAR T therapy for relapsed/ refractory multiple myeloma

BMC Medical Research Methodology, 2022
Background Our aim was to extend traditional parametric models used to extrapolate survival in cost-effectiveness analyses (CEAs) by integrating individual-level patient data (IPD) from a clinical trial with estimates from experts regarding long-term ...
Dieter Ayers, Shannon Cope, Kevin Towle, Ali Mojebi, Thomas Marshall, Devender Dhanda   +5 more
doaj   +1 more source

A Path to Improved Alzheimer’s Care: Simulating Long-Term Health Outcomes of Lecanemab in Early Alzheimer’s Disease from the CLARITY AD Trial

Neurology and Therapy, 2023
Introduction Alzheimer’s disease (AD), a progressive neurodegenerative disease, is the main cause of dementia and one of the leading causes of death for elderly people in the USA.
Amir Abbas Tahami Monfared, Weicheng Ye, Aditya Sardesai, Henri Folse, Ameya Chavan, Elena Aruffo, Quanwu Zhang   +6 more
doaj   +1 more source

Estimated Societal Value of Lecanemab in Patients with Early Alzheimer’s Disease Using Simulation Modeling

Neurology and Therapy, 2023
Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with memory, cognitive, and behavioral deficits, and brings significant economic burden on caregivers and healthcare systems.
Amir Abbas Tahami Monfared, Weicheng Ye, Aditya Sardesai, Henri Folse, Ameya Chavan, Kang Kang, Quanwu Zhang   +6 more
doaj   +1 more source

Recent changes to adult national immunization programs for pneumococcal vaccination in Europe and how they impact coverage: A systematic review of published and grey literature

Human Vaccines & Immunotherapeutics, 2023
Despite widespread use of pneumococcal vaccines throughout Europe, the burden of pneumococcal disease (PD) in adults is considerable. To mitigate this burden, National Immunization Technical Advisory Groups (NITAGs) and Health Technology Assessment (HTA)
Stuti Arya, Nicholas Norton, Puneet Kaushik, Agnes Brandtmüller, Eleana Tsoumani   +4 more
doaj   +1 more source

Vulnerability of populations to malaria after indoor residual spraying is withdrawn from areas where its use has previously been sustained: a protocol for a systematic review

BMJ Open, 2022
Introduction With its proven effectiveness, indoor residual spraying (IRS) as a malaria vector control strategy forms one of the reliable vector control strategies, especially when at least 80% of the population is covered.
Edward Kayongo, Rhona Mijumbi-Deve, Philip Orishaba, Pastan Lusiba, Caroline Nakalema, Peter Kasadha, Perez Kirya, Ismael Kawooya   +7 more
doaj   +1 more source

Public health impact of UK COVID-19 booster vaccination programs during Omicron predominance

Expert Review of Vaccines, 2023
Background We aimed to estimate the public health impact of booster vaccination against COVID-19 in the UK during an Omicron-predominant period. Research design and methods A dynamic transmission model was developed to compare public health outcomes for ...
Diana Mendes, Ruth Chapman, Elena Aruffo, Peter Gal, Jennifer L. Nguyen, Libby Hamson, Manuela Di Fusco, Carole Czudek, Jingyan Yang   +8 more
doaj   +1 more source

Early Childhood Development Programs in Low Middle-Income Countries for Rearing Healthy Children: A Systematic Review [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Early Childhood Development (ECD) includes physical, social, emotional, cognitive and motor development in first eight years of life. Positive parenting, strong families, and encouraging, stimulating environments are critical to a child’s ...
Mahalaqua Nazli Khatib, Abhay Gaidhane, Mahjabeen Ahmed, Deepak Saxena, Zahiruddin Quazi Syed   +4 more
doaj   +1 more source

Correlation Between Early Time-to-Event Outcomes and Overall Survival in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Receiving Definitive Chemoradiation Therapy: Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
BackgroundOverall survival (OS) is the most patient-relevant outcome in oncology; however, in early cancers, large sample sizes and extended follow-up durations are needed to detect statistically significant differences in OS between interventions.
Christopher M. Black, Sam Keeping, Ali Mojebi, Karthik Ramakrishnan, Diana Chirovsky, Navneet Upadhyay, Dylan Maciel, Dieter Ayers   +7 more
doaj   +1 more source

Utility value estimates in cardiovascular disease and the effect of changing elicitation methods: a systematic literature review

Health and Quality of Life Outcomes, 2020
Objective Identify the most recent utility value estimates for cardiovascular disease (CVD) via systematic literature review (SLR) and explore trends in utility elicitation methods in the last 6 years.
Marissa Blieden Betts, Pratik Rane, Evelien Bergrath, Madhura Chitnis, Mohit Kumar Bhutani, Claudia Gulea, Yi Qian, Guillermo Villa   +7 more
doaj   +1 more source