Results 41 to 50 of about 9,419,823 (304)

Developing a fully automated evidence synthesis tool for identifying, assessing and collating the evidence

, 2021
Evidence synthesis is a key element of evidence-based medicine. However, it is currently hampered by being labour intensive meaning that many trials are not incorporated into robust evidence syntheses and that many are out of date.
Price, Christopher, Edwards, Jonny, Hanbury, Allan, Zlabinger, Markus, Bampoulidis, Alexandros, Brassey, Jon; orcid:   +5 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Diabetes health coach in individuals with type 2 diabetes: A systematic review and meta analysis of quadruple aim outcomes

Frontiers in Endocrinology, 2022
BackgroundAs diabetes self-management necessitates life-long learning, behaviour change, support, and monitoring, health coaching is a promising intervention to assist individuals in more than just meeting glycemic goals and glycated hemoglobin (A1C ...
Megan Racey, Milos Jovkovic, Paige Alliston, Muhammad Usman Ali, Diana Sherifali   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Qualitative Evidence Synthesis

Abstract Qualitative evidence synthesis (QES) offers a method for presenting patients’ attitudes, beliefs, and experiences from multiple qualitative studies. It is used in health technology assessments (HTAs) to understand diverse patient perspectives alongside quantitative evidence of clinical and cost effectiveness.
Booth, A., Fryer, K.
openaire   +3 more sources

Quality of Life in Mild Cognitive Impairment and Mild Dementia Associated with Alzheimer’s Disease: A Systematic Review

Neurology and Therapy
Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) have a profound impact on patients' quality of life (QoL), with progressive declines occurring as the disease advances.
Joanna Campbell, Louis Lavoie, Mariana Farraia, Rachel Huelin, Quanwu Zhang, Amir Abbas Tahami Monfared   +5 more
doaj   +1 more source

Evidence Synthesis for Stochastic Epidemic Models

Statistical Science, 2018
In recent years the role of epidemic models in informing public health policies has progressively grown. Models have become increasingly realistic and more complex, requiring the use of multiple data sources to estimate all quantities of interest. This review summarises the different types of stochastic epidemic models that use evidence synthesis and ...
Birrell, Paul J, De Angelis, Daniela, Presanis, Anne M   +2 more
openaire   +5 more sources

Effects of conservation interventions on marine fish: a protocol for subject-wide evidence synthesis

, 2019
The protocol for a subject-wide evidence synthesis of the effects of conservation interventions on marine ...
Conservation Evidence
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Evidence Synthesis International (ESI): Position Statement [PDF]

, 2020
This paper is the initial Position Statement of Evidence Synthesis International, a new partnership of organizations that produce, support and use evidence synthesis around the world.
Ritskes-hoitinga, Merel, Tovey, David, Pullin, Andrew S, Gough, David, Gough, D., Tovey, D, Littell, J, Langlois, E., Littell, Julia, Yost, J, White, H., Langlois, Etienne, Lund, H., Jamtvedt, Gro, Merlin, T., Masset, E., Masset, Edoardo, Røttingen, John-arne, Lotfi, T., Sena, Emily, Sena, E, Langlois, E, Jamtvedt, G, Lotfi, T, Tovey, D., Stewart, Ruth, Lotfi, Tamara, Gough, D, Lund, Hans, Davies, P, Merlin, T, White, Howard, Sena, E., Yost, Jennifer, Pullin, AS, Grimshaw, J, Ritskes-Hoitinga, M., Pullin, Andrew S., Grimshaw, Jeremy, Pullin, A.S., White, H, Grimshaw, J., Davies, Phil, Merlin, Tracy, Lund, H, Ritskes-Hoitinga, M, Røttingen, J.A., Stewart, R., Littell, J., Røttingen, J-A, Masset, E, Davies, P., Langlois, Etienne V., Jamtvedt, G., Stewart, R, Yost, J.   +55 more
core   +2 more sources