Results 51 to 60 of about 9,419,823 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Gender and other intersecting factors in antimicrobial resistance for infectious diseases of poverty: a systematic evidence gap analysis in low- and lower-middle-income countries

BMC Public Health
Background Gender influences health outcomes by affecting exposure to risk factors, healthcare access, and health-seeking behaviours. Yet, many studies fail to consider how these gendered experiences interact with other social factors, such as age ...
Dhanajayan Govindan, Yuvaraj Krishnamoorthy, Marie Gilbert Majella, Monica Karunakaran   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Differences in patient-centered burdens and economic outcomes based on sociodemographic characteristics and social determinants of health: a scoping review

Frontiers in Public Health
BackgroundWe conducted a scoping review to examine how patient-centered burdens and economic outcomes (PCBEOs) vary across sociodemographic characteristics and social determinants of health (SDoH) among U.S.
Sophia D’Angelo, Sydney Kirsch, Ella Shenkar, Olga Khavjou, Kristen Giombi   +4 more
doaj   +1 more source

Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation

Health Technology Assessment, 2016
Background: End-stage renal disease is a long-term irreversible decline in kidney function requiring kidney transplantation, haemodialysis or peritoneal dialysis.
Marcela Haasova, Tristan Snowsill, Tracey Jones-Hughes, Louise Crathorne, Chris Cooper, Jo Varley-Campbell, Ruben Mujica-Mota, Helen Coelho, Nicola Huxley, Jenny Lowe, Jan Dudley, Stephen Marks, Chris Hyde, Mary Bond, Rob Anderson   +14 more
doaj   +1 more source

Developing a definition of biofortification through the synthesis of food biofortification publications: A scoping review protocol

, 2022
Objective: The objective of this review is to develop a definition of biofortification through the synthesis of food biofortification publications and to document the breadth of the research on this topic.
https://orcid.org/0000-0001-9052-0816 Walton, Jenny, Kellogg, Julianne A.; Klarquist, Emily F.; Waziri, Aichatou D.; Luftig, David; Carbonero, Franck; Aytekin, Destan; Walton, Jenny   +1 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Lutein/zeaxanthin intake and visual outcomes in adults with healthy eyes: Qualitative gap analysis

Cogent Medicine, 2019
Purpose: Scientific evidence suggests a role for lutein and zeaxanthin, in visual function. The purpose of this research was to summarize the data related to lutein/zeaxanthin intake and visual outcomes in adults with healthy eyes using evidence mapping ...
Gowri Raman, Danielle Haslam, Esther Avendano, Elizabeth J. Johnson   +3 more
doaj   +1 more source

Research waste in diagnostic trials: a methods review evaluating the reporting of test-treatment interventions

BMC Medical Research Methodology, 2017
Background The most rigorous method for evaluating the effectiveness of diagnostic tests is through randomised trials that compare test-treatment interventions: complex interventions comprising episodes of testing, decision-making and treatment.
Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Sian Taylor-Phillips, Clare Davenport, Chris Hyde, Jonathan J. Deeks   +5 more
doaj   +1 more source