Results 71 to 80 of about 1,370,629 (264)

Pulmonary Function Decline in Alpha-1 Antitrypsin Deficiency: A Systematic Review and Meta-Analysis

International Journal of COPD
Alice M Turner,1 Priscilla Wittkopf,2 Caroline von Wilamowitz-Moellendorff,2 Kyle Fahrbach,3 Mariana Farraia,4 May Hagiwara,5 Ed G Marins,5 Anne E Wyman,5 Lisi Wang,5 Suna Park5 1School of Health Sciences, University of Birmingham, Birmingham, UK ...
Turner AM, Wittkopf P, von Wilamowitz-Moellendorff C, Fahrbach K, Farraia M, Hagiwara M, Marins EG, Wyman AE, Wang L, Park S   +9 more
doaj  

Contextual factors and G6PD diagnostic testing: a scoping review and evidence and gap map

Malaria Journal
Background Testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important consideration regarding treatment for malaria. G6PD deficiency may lead to haemolytic anaemia during malaria treatment and, therefore, determining G6PD deficiency ...
Timothy Hugh Barker, Grace McKenzie McBride, Mafalda Dias, Carrie Price, Zachary Munn   +4 more
doaj   +1 more source

Burden of carbapenem non-susceptible infections in high-risk patients: systematic literature review and meta-analysis

Antimicrobial Resistance and Infection Control, 2020
Background Owing to their resistance to an important class of antibiotics, the prevention and treatment of carbapenem-resistant (CR)/non-susceptible Gram-negative (GN) infections has become an important public health objective.
Esther E. Avendano, Gowri Raman, Jeffrey Chan, Eilish McCann   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Phenome-wide analysis of downstream health outcomes following second-line antidiabetic agent prescriptions in All of Us

Nature Communications
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for type 2 diabetes (T2D) and weight management, yet their real-world health impacts remain understudied.
Maxwell Salvatore, Bingyu Zhang, Huilin Tang, Yiwen Lu, Dazheng Zhang, Ting Zhou, Yuan Lu, Anastassia Amaro, Marylyn D. Ritchie, Yong Chen   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Climate change and health in South Asia: A systematic mapping

The Journal of Climate Change and Health
Introduction: Climate change is a major threat to human health in South Asia. We mapped existing research on climate change and health in South Asia, identified research gaps, and developed a list of research questions (RQs) to inform a research priority
Inika Sharma, Bhanushree Soni, Manish Barik, Jyoti Tyagi, Samiksha Ingale, Chandni Singh, Gautam I. Menon, Soumyadeep Bhaumik   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source