Results 91 to 100 of about 9,419,823 (304)

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Using visual methods to further enhance qualitative evidence synthesis [PDF]

Background The use of visual methods in qualitative evidence synthesis (QES) adds a valuable dimension to the synthesis process by enhancing understanding and knowledge generation. Visual methods are currently underused and underreported in QES. Methods
France, Emma, Noyes, Jane, Silveira Bianchim, Mayara   +2 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Phenome-wide analysis of downstream health outcomes following second-line antidiabetic agent prescriptions in All of Us

Nature Communications
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for type 2 diabetes (T2D) and weight management, yet their real-world health impacts remain understudied.
Maxwell Salvatore, Bingyu Zhang, Huilin Tang, Yiwen Lu, Dazheng Zhang, Ting Zhou, Yuan Lu, Anastassia Amaro, Marylyn D. Ritchie, Yong Chen   +9 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Climate change and health in South Asia: A systematic mapping

The Journal of Climate Change and Health
Introduction: Climate change is a major threat to human health in South Asia. We mapped existing research on climate change and health in South Asia, identified research gaps, and developed a list of research questions (RQs) to inform a research priority
Inika Sharma, Bhanushree Soni, Manish Barik, Jyoti Tyagi, Samiksha Ingale, Chandni Singh, Gautam I. Menon, Soumyadeep Bhaumik   +7 more
doaj   +1 more source

A realist synthesis of the evidence on outreach programmes for health improvement of Traveller Communities [PDF]

, 2016
Background: Improving the health of Traveller Communities is an international public health concern but there is little evidence on effective interventions.
M. Lhussier, Lhussier, Monique, Forster, Natalie, S. M. Carr, N. Forster, Carr, Susan   +5 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Equity in evidence synthesis

The International Journal of Information, Diversity, & Inclusion
This research explored the impact of race and ethnicity on Black, Indigenous, and People Of Color (BIPOC) and their participation throughout the production of evidence synthesis in information science research.  The study also analyzed the potential for evidence synthesis team reviewers to face pressure to modify their results based on their ...
Rachel Keiko Stark, Laura Gaeta
openaire   +3 more sources

Evidence Synthesis Strategies to Enhance Evidence-Based Practice [PDF]

, 2013
Session presented on: Monday, July 22, 2013: Evidence-based practice requires multiple steps including the synthesis of evidence. Despite its importance, the synthesis of evidence is often a misunderstood step.
Weeks, Susan Mace
core   +1 more source