Results 81 to 90 of about 1,370,629 (264)

Equity in evidence synthesis

The International Journal of Information, Diversity, & Inclusion
This research explored the impact of race and ethnicity on Black, Indigenous, and People Of Color (BIPOC) and their participation throughout the production of evidence synthesis in information science research.  The study also analyzed the potential for evidence synthesis team reviewers to face pressure to modify their results based on their ...
Rachel Keiko Stark, Laura Gaeta
openaire   +3 more sources

The Impact on Systematic Reviews of Risk of Bias Assessment Changes From Conference Abstracts to Full Text

Cochrane Evidence Synthesis and Methods
Conference abstracts are commonly included in systematic reviews of evidence. Due to limitations in word count, conference abstracts often lack data or information. This causes issues for the assessment of risk of bias (RoB).
Ryan P. W. Kenny, Katie Twentyman, Dawn Craig, Nick Meader, Gill Norman   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Enablers and barriers to antimicrobial stewardship for upper respiratory tract infections in Kosovo’s primary care: a qualitative study protocol

BMJ Open
Introduction Upper respiratory tract infections (URTIs) are one of the most common reasons for primary care visits, yet often do not require treatment with antibiotics.
Ilir Hoxha, Lul Raka, Shaip Krasniqi, Arianit Jakupi, Riaz Agahi, Erza Selmani, Nandini Sreenivasan, Ahmad Wesal Zaman, Lumi Lila, Robert Leo Skov   +9 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Diagnostic accuracy of point-of-care tests for acute respiratory infection: a systematic review of reviews

Health Technology Assessment
Background Acute respiratory infections are a common reason for consultation with primary and emergency healthcare services. Identifying individuals with a bacterial infection is crucial to ensure appropriate treatment.
Katie E Webster, Tom Parkhouse, Sarah Dawson, Hayley E Jones, Emily L Brown, Alastair D Hay, Penny Whiting, Christie Cabral, Deborah M Caldwell, Julian PT Higgins   +9 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Cochrane India and Evidence Synthesis

Journal of Medical Evidence, 2023
Meenu Singh, Anju Pradhan
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source