Results 101 to 110 of about 3,583,013 (282)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Risk scores to guide referral decisions for people with suspected ovarian cancer in secondary care: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2018
Background: Ovarian cancer is the sixth most common cancer in UK women and can be difficult to diagnose, particularly in the early stages. Risk-scoring can help to guide referral to specialist centres.
Marie Westwood, Bram Ramaekers, Shona Lang, Sabine Grimm, Sohan Deshpande, Shelley de Kock, Nigel Armstrong, Manuela Joore, Jos Kleijnen   +8 more
doaj   +1 more source

Systematic reviews [PDF]

Age and Ageing, 2001
D J, Stott, M, Barber
openaire   +2 more sources

Dissemination Bias in Systematic Reviews of Animal Research: A Systematic Review

PLoS ONE, 2014
Background: Systematic reviews of preclinical studies, in vivo animal experiments in particular, can influence clinical research and thus even clinical care. Dissemination bias, selective dissemination of positive or significant results, is one of the major threats to validity in systematic reviews also in the realm of animal studies.
Müller, Katharina Felicitas, Briel, Matthias, Strech, Daniel, Meerpohl, Jörg J., Lang, Britta, Motschall, Edith, Gloy, Viktoria, Lamontagne, Francois, Bassler, Dirk   +8 more
openaire   +7 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Review: A systematic review of dairy cow health, welfare, and behaviour in year-round loose range housing

Animal
This systematic review compares the health, welfare, and behaviour of dairy cows in year-round loose housing systems against those kept in other housing systems in temperate regions. Year-round loose housing systems comprised housing where dairy cows had
W.J. Harvey, L. Petrokofsky, M.W. Jordon, G. Arnott, L.W. von Walter, A. Malik, T. Carter, L.S. Wade, G. Petrokofsky   +8 more
doaj   +1 more source

A Systematic Approach to Systematic Reviews [PDF]

AORN Journal, 2022
openaire   +2 more sources

Frankincense: systematic review [PDF]

BMJ, 2008
To assess evidence from randomised clinical trials about the effectiveness of extracts of Boswellia serrata (frankincense).Systematic review.Electronic searches on Medline, Embase, Cinahl, Amed, and Cochrane Library. Hand searches of conference proceedings, bibliographies, and departmental files.All randomised clinical trials of B serrata extract as a ...
openaire   +2 more sources