Results 111 to 120 of about 708,426 (318)

Social capital and health: A systematic review of systematic reviews

open access: yesSSM - Population Health, 2019
There are many systematic reviews on social capital (SC) and various health outcomes, but each of these reviews shows one piece of the larger SC and health puzzle. The aim of this research was to systematically review systematic reviews on SC and health, in order to provide an overview of existing evidence and to identify strategies for future research.
Ehsan, Annahita   +3 more
openaire   +5 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation testing in adults with locally advanced or metastatic non-small cell lung cancer: a systematic review and cost-effectiveness analysis

open access: yesHealth Technology Assessment, 2014
Background: Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Some epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutations make tumours responsive to treatment with EGFR-TK inhibitors (EGFR-TKIs) but less responsive ...
Marie Westwood   +8 more
doaj   +1 more source

Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews

open access: yes, 2016
© 2016 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of this overview is to summarise the evidence from Cochrane systematic reviews regarding the effects of antenatal ...
Makrides, M   +11 more
core   +1 more source

Systematic Reviews in Health Research : Meta-Analysis in Context.

open access: yes, 2022
In this Third Edition of the classic Systematic Reviews textbook, now titled Systematic Reviews in Health Research, a team of distinguished researchers deliver a comprehensive and authoritative guide to the rapidly evolving area of systematic reviews and

core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Contrast-enhanced ultrasound using SonoVue® (sulphur hexafluoride microbubbles) compared with contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging for the characterisation of focal liver lesions and detection of liver metastases: a systematic review and cost-effectiveness analysis

open access: yesHealth Technology Assessment, 2013
Background: Medical imaging techniques are important in the management of many patients with liver disease. Unenhanced ultrasound examinations sometimes identify focal abnormalities in the liver that may require further investigation, primarily to ...
M Westwood   +10 more
doaj   +1 more source

Reporting Systematic Reviews: Some Lessons from a Tertiary Study [PDF]

open access: yes, 2018
Context: Many of the systematic reviews published in software engineering are related to research or methodological issues and hence are unlikely to be of direct benefit to practitioners or teachers.

core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Treatments for women with gestational diabetes mellitus: An overview of Cochrane systematic reviews

open access: yes, 2016
This is the protocol for a review and there is no abstract. The objectives are as follows: The aim is to provide a comprehensive synthesis of evidence from randomised trials in relevant published Cochrane systematic reviews of interventions for treating ...
Martis, R   +4 more
core   +1 more source

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