Results 131 to 140 of about 14,049,576 (343)

An overview of systematic reviews on the public health consequences of social isolation and loneliness.

Public Health, 2017
OBJECTIVES Social isolation and loneliness have been associated with ill health and are common in the developed world. A clear understanding of their implications for morbidity and mortality is needed to gauge the extent of the associated public health ...
N. Leigh-Hunt, D. Bagguley, K. Bash, V. Turner, S. Turnbull, Nicole K Valtorta, W. Caan   +6 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A cloud-based medical device for predicting cardiac risk in suspected coronary artery disease: a rapid review and conceptual economic model

Health Technology Assessment
Background The CaRi-Heart® device estimates risk of 8-year cardiac death, using a prognostic model, which includes perivascular fat attenuation index, atherosclerotic plaque burden and clinical risk factors.
Marie Westwood, Nigel Armstrong, Eline Krijkamp, Mark Perry, Caro Noake, Apostolos Tsiachristas, Isaac Corro-Ramos   +6 more
doaj   +1 more source

Crowdsourcing Paper Screening in Systematic Literature Reviews

, 2017
Literature reviews allow scientists to stand on the shoulders of giants, showing promising directions, summarizing progress, and pointing out existing challenges in research.
Benatallah, Boualem, Caforio, Valentina, Casati, Fabio, Krivosheev, Evgeny   +3 more
core   +2 more sources

Introducing EMMIE: An evidence rating scale to encourage mixed-method crime prevention synthesis reviews [PDF]

, 2015
Objectives This short report describes the need for, and the development of, a coding system to distil the quality and coverage of systematic reviews of the evidence relating to crime prevention interventions.
A Sidebottom, AA Braga, AE Perry, AI Huffcutt, BJ Shea, C McDougal, CE Gill, D Moher, D Moher, D Rosenbaum, D Weisburd, DT Campbell, E Elm von, FB Bryant, G Farrell, G Ogrinc, G Wong, GH Guyatt, J Higgins, J Knutsson, JQ Wilson, K Adetugbo, Kate J. Bowers, KF Schulz, L Sherman, LV Hedges, LV Hedges, M Borenstein, M Borenstein, M Lipsey, M Lipsey, M Petticrew, N Cartwright, N Tilley, Nick Tilley, R Pawson, R Pawson, R Pawson, Shane D. Johnson, WA Stock   +39 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Faecal immunochemical tests to triage patients with lower abdominal symptoms for suspected colorectal cancer referrals in primary care: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2017
Background: Colorectal cancer (CRC) is the third most common cancer in the UK. Presenting symptoms that can be associated with CRC usually have another explanation.
Marie Westwood, Isaac Corro Ramos, Shona Lang, Marianne Luyendijk, Remziye Zaim, Lisa Stirk, Maiwenn Al, Nigel Armstrong, Jos Kleijnen   +8 more
doaj   +1 more source

Risk factors for development of lower limb osteoarthritis in physically-demanding occupations like the military: A narrative umbrella review [PDF]

, 2019
OBJECTIVES: Osteoarthritis (OA) is a common disorder which affects the joints. As relationships between occupational factors and lower limb OA have been widely studied in systematic reviews, the aim of this umbrella review was to synthesize their key ...
Canetti, Elisa, Knapik, Joseph, Orr, Rob Marc, Pope, Rodney R, Schram, Ben   +4 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation testing in adults with locally advanced or metastatic non-small cell lung cancer: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2014
Background: Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Some epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutations make tumours responsive to treatment with EGFR-TK inhibitors (EGFR-TKIs) but less responsive ...
Marie Westwood, Manuela Joore, Penny Whiting, Thea van Asselt, Bram Ramaekers, Nigel Armstrong, Kate Misso, Johan Severens, Jos Kleijnen   +8 more
doaj   +1 more source