Results 61 to 70 of about 708,426 (318)

Systematic Review and Network Meta‐Analysis on the Efficacy of Evolocumab and Other Therapies for the Management of Lipid Levels in Hyperlipidemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors evolocumab and alirocumab substantially reduce low‐density lipoprotein cholesterol (LDL‐C) when added to statin therapy in patients who need additional LDL‐C reduction ...
Peter P. Toth, Gillian Worthy, Shravanthi R. Gandra, Naveed Sattar, Sarah Bray, Lung‐I. Cheng, Ian Bridges, Gavin M. Worth, Ricardo Dent, Carol A. Forbes, Sohan Deshpande, Janine Ross, Jos Kleijnen, Erik S. G. Stroes   +13 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

The quality of COVID-19 systematic reviews during the coronavirus 2019 pandemic: an exploratory comparison

Systematic Reviews
Background The unprecedented volume and speed at which COVID-19-related systematic reviews (SRs) may have been produced has raised questions regarding the quality of this evidence.
Kevin T. McDermott, Mark Perry, Willemijn Linden, Rachel Croft, Robert Wolff, Jos Kleijnen   +5 more
doaj   +1 more source

Role of the faecal immunochemical test in patients with risk-stratified suspected colorectal cancer symptoms: A systematic review and meta-analysis to inform the ACPGBI/BSG guidelines

The Lancet Regional Health. Europe, 2022
Summary: Background: The UK National Institute for Health and Care Excellence (NICE), recommended in 2017 the use of the faecal immunochemical test (FIT) to guide investigations in patients presenting with NICE-defined low-risk symptoms suspicious for ...
Richard Booth, Rachel Carten, Nigel D'Souza, Marie Westwood, Jos Kleijnen, Muti Abulafi   +5 more
doaj   +1 more source

A systematic review of reviews of interventions to promote mental health and prevent mental health problems in children and young people [PDF]

, 2007
Background: There is a growing policy imperative to promote positive mental health as well as preventing the development of mental health problems in children.
Ruth Tennant, Day, Crispin, Jane Barlow, Sarah Stewart‐Brown, Crispin Day, Goens, Cristina, Tennant, Ruth, Cristina Goens, Barlow, Jane, Stewart-Brown, Sarah L.   +9 more
core   +1 more source

The frequency of maternal morbidity: A systematic review of systematic reviews [PDF]

International Journal of Gynecology & Obstetrics, 2018
Estimates of the burden of maternal morbidity are patchy.To conduct a systematic review of systematic reviews of maternal conditions to: (1) make available the most up-to-date frequency estimates; (2) identify which conditions do not have reliable estimates; and (3) scrutinize the quality of the available reviews.We searched Embase, MEDLINE, and CINAHL,
Gon, Giorgia, Leite, Andreia, Calvert, Clara, Woodd, Susannah, Graham, Wendy J, Filippi, Veronique   +5 more
openaire   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Accuracy and clinical effectiveness of fetal growth monitoring strategies for the prediction of small for gestational age at birth: a systematic review and meta-analysis

Health Technology Assessment
Background Smallness for gestational age has been associated with an increased risk of neonatal/fetal adverse outcomes. The Healthcare Safety Investigation Branch has issued a safety recommendation aimed at improving fetal growth monitoring strategies ...
Evangelos Danopoulos, Nigel Armstrong, Kevin McDermott, Jiongyu Chen, Xiaoyu Tian, Caro Noake, Marie Westwood   +6 more
doaj   +1 more source

ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis

Health Technology Assessment, 2016
Background: Allergy is a form of immune-mediated exaggerated sensitivity (hypersensitivity) to a substance that is either inhaled, swallowed, injected or comes into contact with the skin. Foreign substances that provoke allergies are called allergens. It
Marie Westwood, Bram Ramaekers, Shona Lang, Nigel Armstrong, Caro Noake, Shelley de Kock, Manuela Joore, Johan Severens, Jos Kleijnen   +8 more
doaj   +1 more source

Systematic reviewers' perspectives on replication of systematic reviews: A survey

Cochrane Evidence Synthesis and Methods, 2023
AbstractBackgroundReplication is essential to the scientific method. It is unclear what systematic reviewers think about the replication of systematic reviews (SRs). Therefore, we aimed to explore systematic reviewers' perspectives on (a) the definition and importance of SR replication; (b) incentives and barriers to conducting SR replication; and (c ...
Phi‐Yen Nguyen, Joanne E. McKenzie, Daniel G. Hamilton, David Moher, Peter Tugwell, Fiona M. Fidler, Neal R. Haddaway, Julian P. T. Higgins, Raju Kanukula, Sathya Karunananthan, Lara J. Maxwell, Steve McDonald, Shinichi Nakagawa, David Nunan, Vivian A. Welch, Matthew J. Page   +15 more
openaire   +3 more sources