Results 291 to 300 of about 1,783,022 (384)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Step-by-step guide and checklists for selecting and conducting an evidence synthesis study using a framework for approaches and methods in evidence synthesis (FRAMES). [PDF]

PeerJ
Dwivedi AK.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Finding the ultimate truth: What role remains for systematic reviews and meta-analysis? [PDF]

J Oral Biol Craniofac Res
Rattan V, Jena AK.
europepmc   +1 more source

Mindfulness for people with long-term conditions and their family caregivers: a systematic review [PDF]

, 2019
Atteih, Badr, Barnett, Bauer, Beck, Ben Parkinson, Birnie, Bishop, Bohlmeijer, Camak, Carison, Carmody, Cash, Centre for Reviews and Dissemination, Clark, Cohen, De Ridder, Deek, Dixon-Woods, Dobkin, Evelyn McElhinney, Family Caregiver Alliance, Friis, Gambrel, Gotink, Greenwood, Hankin, Hou, Jaffray, Jo Booth, Kabat-Zinn, Kabat-Zinn, Kastner, Katon, Kershaw, King, Kroenke, Lawrence, Lengacher, Li, Maggie Lawrence, Marconi, Martire, Martire, Massimi, McNair, Meyer, Moher, Pace, Paller, Parkinson, Parsons, Radloff, Rajan, Regan, Ricci-Cabello, Rusbult, Schellekens, Smith, Snaith, Spanier, Spielberger, Spitzer, Teasdale, Traa, van den Hurk, Whitebird, Williamson, Wolff, Wood, World Health Organization, Yesavage   +71 more
core   +1 more source

Development of a Training Program for Meta-Analytical Research: A Novel Approach to Minimizing Errors in Medical Systematic Reviews and Meta-Analyses [PDF]

Ayad Palani, Hiva Alipour, Ashok Agarwal, Andrea Crafa, Ramadan Saleh, Bahadır Şahin, Wael Zohdy, Damayanthi Durairajanayagam, Fotios Dimitriadis, Erman Ceyhan, Rossella Cannarella, Tuncay Toprak, Widi Atmoko, Marco Falcone, Naveen Kumar, Giorgio Ivan Russo, Trang Nguyen, Gökhan Çalık, Deniz Kulaksız, Konstantinos Makarounis, Kadir Böcü, Fikri Rizaldi, Ricky Adriansjah, Hakan Keskin, Vineet Malhotra, Nguyen Ho Vinh Phuoc, Sezgin Güneş, Carlo Giulioni, Ahmad Motawi, Germar‐Michael Pinggera, Imad Ziouziou, Gökhan Çeker, Christopher C.K. Ho, Fereshteh Dardmeh, Fahmi Bahar, Nazim Gherabi, Parisa Dolati, Priyank Kothari, Aram Adamyan, Rupin Shah   +39 more
openalex   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Silence in physician clinical practice: a scoping review protocol. [PDF]

PLoS One
Kelly MA, Rivera S, McClurg C, Sweeney C, Mosca S, McLeod E, Bennett D, Brown M.   +7 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Midline catheter versus peripheral intravenous catheter for intravenous treatment in hospitalized children. [PDF]

Cochrane Database Syst Rev
Miura S, Shinzato Y, Abe M, Sakai H, Yasuo S, Saito M, Terasaka Y, Tomida M, Yasuda H.   +8 more
europepmc   +1 more source