Results 111 to 120 of about 11,519,005 (304)
Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala +18 morewiley +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more sourceGlobal, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet, 2017 Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease.E. Gakidou, A. Afshin, A. Abajobir, K. H. Abate, C. Abbafati, K. Abbas, F. Abd-Allah, A. Abdulle, S. Abera, V. Aboyans, L. Abu-Raddad, N. Abu-Rmeileh, G. Abyu, I. Adedeji, O. Adetokunboh, M. Afarideh, Anurag Agrawal, S. Agrawal, A. Kiadaliri, H. Ahmadieh, M. Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, R. Akinyemi, N. Akseer, Fares Alahdab, Z. Al-Aly, K. Alam, N. Alam, Tahiya Alam, D. Alasfoor, K. Alene, Komal Ali, Reza Alizadeh-Navaei, A. Alkerwi, F. Alla, P. Allebeck, R. Al-Raddadi, U. Alsharif, K. Altirkawi, N. Alvis-Guzmán, Azmeraw T. Amare, E. Amini, W. Ammar, Y. Amoako, H. Ansari, J. Antó, C. Antonio, P. Anwari, N. Arian, J. Ärnlöv, A. Artaman, K. Aryal, H. Asayesh, S. W. Asgedom, T. Atey, L. Ávila-Burgos, Euripide Avokpaho, A. Awasthi, P. Azzopardi, U. Bacha, A. Badawi, K. Balakrishnan, S. Ballew, A. Barać, Ryan Barber, S. Barker-Collo, T. Bärnighausen, S. Barquera, L. Barregard, L. Barrero, C. Batis, K. Battle, B. Baune, J. Beardsley, Neeraj Bedi, E. Beghi, M. Bell, D. Bennett, James R. Bennett, I. Benseñor, A. Berhane, D. F. Berhe, E. Bernabé, B. Betsu, M. Beuran, A. Beyene, A. Bhansali, Z. Bhutta, B. Bikbov, C. Birungi, S. Biryukov, C. Blosser, D. Boneya, I. Bou-Orm, M. Brauer, N. Breitborde, H. Brenner, T. Brugha, L. Bulto, Bl Baumgarner, Z. Butt, Lucero Cahuana-Hurtado, Rosario Cárdenas, J. Carrero, C. Castañeda-Orjuela, F. Catalá-López, Kelly M. Cercy, Hsing-Yi Chang, F. Charlson, Odgerel Chimed-Ochir, V. Chisumpa, Abdulaal Chitheer, H. Christensen, D. Christopher, M. Cirillo, A. Cohen, H. Comfort, C. Cooper, J. Coresh, Leslie Cornaby, P. Cortesi, M. Criqui, J. Crump, L. Dandona, R. Dandona, J. Neves, G. Davey, D. Davițoiu, K. Davletov, B. Courten, L. Degenhardt, Selina Deiparine, R. Dellavalle, Kebede Deribe, A. Deshpande, S. Dharmaratne, E. Ding, S. Djalalinia, H. Do, K. Dokova, D. Doku, E. Dorsey, T. Driscoll, M. Dubey, B. Duncan, Sarah Duncan, Natalie Ebert, H. Ebrahimi, Z. El-Khatib, A. Enayati, A. Endries, S. Ermakov, H. Erskine, B. Eshrati, S. Eskandarieh, A. Esteghamati, Kara Estep, E. J. Faraon, C. Farinha, Andre Faro, F. Farzadfar, K. Fay, V. Feigin, S. Fereshtehnejad, João Fernandes, A. Ferrari, T. R. Feyissa, I. Filip, F. Fischer, C. Fitzmaurice, A. Flaxman, N. Foigt, Kyle Foreman, J. Frostad, N. Fullman, Thomas Fürst, J. Furtado, M. Ganji, A. García-Basteiro, T. Gebrehiwot, J. Geleijnse, Ayele Geleto, Bikila Lencha Gemechu, H. Gesesew, P. Gething, A. Ghajar, K. Gibney, P. Gill, R. Gillum, A. Z. Giref, Melkamu Dedefo Gishu, G. Giussani, W. Godwin, P. Gona, A. Goodridge, S. Gopalani, Y. Goryakin, A. Goulart, Nicholas Graetz, H. Gugnani, Jingwen Guo, Rajeev Gupta, Tanush Gupta, V. Gupta, R. A. Gutiérrez, V. Hachinski, N. Hafezi-Nejad, G. B. Hailu, R. Hamadeh, S. Hamidi, M. Hammami, A. Handal, G. Hankey, H. Harb, H. Hareri, Mohammad Sadegh Hassanvand, Rasmus J. Havmoeller, Caitlin N Hawley, Simon Iain Hay, M. Hedayati, D. Hendrie, I. Heredia-Pi, H. Hoek, N. Horita, H. Hosgood, S. Hostiuc, D. Hoy, M. Hsairi, G. Hu, Hsiang Huang, John J Emmanuel Huang, K. Iburg, C. Ikeda, M. Inoue, C. Irvine, M. Jackson, K. Jacobsen, N. Jahanmehr, M. Jakovljevic, Alejandra Jáuregui, Mehdi Javanbakht, P. Jeemon, L. Johansson, C. Johnson, J. Jonas, M. Jürisson, Z. Kabir, R. Kadel, Amaha Kahsay, R. Kamal, A. Karch, C. Karema, A. Kasaeian, N. Kassebaum, A. Kastor, S. Katikireddi, N. Kawakami, P. Keiyoro, Sefonias Getachew Kelbore, L. Kemmer, A. Kengne, C. Kesavachandran, Y. Khader, I. Khalil, E. Khan, Y. Khang, A. Khosravi, J. Khubchandani, C. Kieling, Daniel H. Kim, J. Y. Kim, Y. Kim, R. Kimokoti, Y. Kinfu, A. Kisa, K. Kissimova-Skarbek, M. Kivimäki, L. Knibbs, A. Knudsen, J. Kopec, S. Kosen, P. Koul, A. Koyanagi, M. Kravchenko, Kristopher J. Krohn, H. Kromhout, B. K. Defo, B. Bicer, G. Kumar, Michael Kutz, H. Kyu, D. Lal, R. Lalloo, T. Lallukka, Q. Lan, V. Lansingh, A. Larsson, Alexander Lee, P. Lee, J. Leigh, J. Leung, M. Levi, Yichong Li, Yongmei Li, Xiaofeng Liang, Misgan Legesse Liben, S. Linn, Patrick Y. Liu, R. Lodha, G. Logroscino, Katherine J. Looker, Alan D. Lopez, S. Lorkowski, P. Lotufo, R. Lozano, R. Lunevicius, E. Macarayan, H. A. E. Razek, M. Razek, M. Majdan, R. Majdzadeh, A. Majeed, R. Malekzadeh, R. Malhotra, D. Malta, A. Mamun, Helena Manguerra, L. Mantovani, C. Mapoma, R. Martin, J. Martínez-Raga, F. R. Martins-Melo, M. Mathur, K. Matsushita, R. Matzopoulos, M. Mazidi, C. McAlinden, J. Mcgrath, S. Mehata, M. Mehndiratta, T. Meier, Y. Melaku, P. Memiah, Z. Memish, W. Mendoza, M. Mengesha, G. Mensah, Gert B. M. Mensink, S. T. Mereta, A. Meretoja, T. Meretoja, H. Mezgebe, R. Micha, Anoushka I Millear, T. Miller, S. Minnig, M. Mirarefin, E. Mirrakhimov, A. Misganaw, S. Mishra, K. Mohammad, Kedir Mohammed Oumer, S. Mohammed, N. Ibrahim, Murali B. V. Mohan, A. Mokdad, L. Monasta, J. M. Hernandez, M. Montico, M. Moradi-Lakeh, Paula Moraga, L. Morawska, S. Morrison, Cliff Mountjoy-Venning, U. Mueller, Erin C. Mullany, Kate Muller, G. Murthy, K. I. Musa, M. Naghavi, A. Naheed, V. Nangia, G. Natarajan, Ionut Negoi, R. Negoi, C. Nguyen, Grant Nguyen, Minh Nguyen, Q. Nguyen, T. H. Nguyen, Emma Nichols, D. N. A. Ningrum, Marika Nomura, V. M. Nong, O. Norheim, B. Norrving, J. Noubiap, C. Obermeyer, F. Ogbo, Hwan-Jung Oh, Olanrewaju Oladimeji, A. Olagunju, T. Olagunju, Pedro R Olivares, H. Olsen, B. Olusanya, J. Olusanya, John Nelson Opio, Eyal Oren, Alberto Ortiz, E. Ota, M. Owolabi, Mahesh Pa, R. Pacella, A. Pana, B. Panda, S. Panda-Jonas, J. Pandian, C. Papachristou, Eun‐Kee Park, C. Parry, S. Patten, G. Patton, David M Pereira, N. Perico, K. Pesudovs, M. Petzold, M. Phillips, J. Pillay, M. Piradov, F. Pishgar, D. Plass, Martin A Pletcher, S. Polinder, S. Popova, R. Poulton, F. Pourmalek, N. Prasad, Carrie Purcell, M. Qorbani, A. Radfar, Anwar Rafay, A. Rahimi-Movaghar, V. Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, M. Rahman, R. Rai, Sasa Rajsic, U. Ram, S. Rawaf, C. Rehm, J. Rehm, R. Reiner, M. Reitsma, L. Reynales-Shigematsu, G. Remuzzi, A. Renzaho, S. Resnikoff, S. Rezaei, A. Ribeiro, J. Rivera, K. Roba, D. Rojas-Rueda, Yesenia Román, R. Room, G. Roshandel, Gregory A. Roth, D. Rothenbacher, Enrico Rubagotti, L. Rushton, Nafis Sadat, M. Safdarian, S. Safi, S. Safiri, R. Sahathevan, Joseph S. Salama, J. Salomon, A. Samy, J. Sanabria, M. Sánchez-Niño, Tania G. Sánchez-Pimienta, D. Santomauro, I. Santos, M. Milicevic, B. Sartorius, Maheswar Satpathy, M. Sawhney, S. Saxena, E. Schaeffner, M. Schmidt, I. Schneider, A. Schutte, D. Schwebel, F. Schwendicke, S. Seedat, S. Sepanlou, Berrin Serdar +499 moresemanticscholar +1 more sourceIntein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more sourceCytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock +10 morewiley +1 more source
