Results 91 to 100 of about 469,724 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Temporal Aggregation and Ordinary Least Squares Estimation of Cointegrating Regressions [PDF]

open access: yes
The paper derives the asymptotic distribution of the ordinary least squares estimator of cointegrating vectors with temporally aggregated time series.
Gabriel Pons Rotger
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Application of Balanced Acceptance Sampling to an Intertidal Survey

open access: yesJournal of Landscape Ecology, 2017
In ecological studies, the population of interest is often spread over a large area. In these studies, obtaining a sample with good spatial coverage is an important feature in the design of a survey.
Abi Naeimeh   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exact methods for comparison of estimation strategies in survey sampling.

open access: yes, 2010
PhDMany strategies in survey sampling depend on large sample approximation formulae for design-based inference on finite population parameters, which are not valid for small samples. We develop an approach using matrix algebra to tackle many problems
Khan, Kaleem Uddin
core  

Insights from a large-scale inventory in the southern Brazilian Atlantic Forest

open access: yesScientia Agricola
: A key issue in large-area inventories is defining a suitable sampling design and the effort required to obtain reliable estimates of species richness and forest attributes, especially in species-diverse forests.
Alexander Christian Vibrans   +5 more
doaj   +1 more source

Purposive sampling in a qualitative evidence synthesis: a worked example from a synthesis on parental perceptions of vaccination communication

open access: yesBMC Medical Research Methodology, 2019
Background In a qualitative evidence synthesis, too much data due to a large number of studies can undermine our ability to perform a thorough analysis.
Heather Ames   +2 more
doaj   +1 more source

The Added Value of Systematic Sampling in In-Bore Magnetic Resonance Imaging-Guided Prostate Biopsy. [PDF]

open access: yesJ Pers Med, 2023
Lazarovich A   +5 more
europepmc   +1 more source

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