Results 111 to 120 of about 2,446,622 (333)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

SDSS-III Baryon Oscillation Spectroscopic Survey: Analysis of Potential Systematics in Fitting of Baryon Acoustic Feature

, 2013
Extraction of the Baryon Acoustic Oscillations (BAO) to percent level accuracy is challenging and demands an understanding of many potential systematic to an accuracy well below 1 per cent, in order ensure that they do not combine significantly when ...
Aubourg, Eric, Cuesta, Antonio J., Eisenstein, Daniel J., Ho, Shirley, Kirkby, Stéphanie Escoffier David, Magaña, Mariana Vargas, Manera, Marc, O'Connell, Ross, Percival, Will J., Ross, Ashley J., Schneider, Donald P., Sánchez, Ariel G., Tinker, Jeremy L., Weaver, Benjamin A., Xu, Xiaoying   +14 more
core  

Small organizations and Title I of the ADA: A survey study in Region 2 [PDF]

, 2019
While both small and large employers cite barriers to employing and advancing individuals with disabilities, some issues are more common among smaller employers than their larger counterparts.
Chang, Hsiao-Ying Vicki, Strobel Gower, Wendy, von Schrader, Sarah   +2 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Ecological and Geological Environment Risk Assessment of Wangwa Mining Area Based on DInSAR Technology

Applied Sciences
Mining activities in coal mining areas have exacerbated ecological and geological environmental risks. To explore the impact of mineral resources on the ecological and geological environment risk (EGER) in coal mining areas, we developed a novel ...
Guorui Wang, Liya Yang, Peixian Li, Xuesong Wang   +3 more
doaj   +1 more source

A systematic search for massive young stars in the Galaxy - the RMS survey [PDF]

, 2004
We have selected red MSX sources (RMS) that have the colours of massive young stellar objects (MYSOs). Our aim is to generate a large, systematically selected sample to address questions such as their luminosity function, lifetimes, clustering and ...
Busfield, AL, Hoare, MG, King, TL, Lumsden, SL, Moore, TLJ, Oudmaijer, RD   +5 more
core   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Trustworthiness of randomized trials in endocrinology—A systematic survey

PLOS ONE, 2019
Trustworthy (i.e. low risk of bias) randomized clinical trials (RCTs) play an important role in evidence-based decision making. We aimed to systematically assess the risk of bias of trials published in high-impact endocrinology journals.We searched the MEDLINE/PubMed database between 2014 and 2016 for phase 2-4 RCTs evaluating endocrine-related ...
José Gerardo González-González, Edgar Gerardo Dorsey-Treviño, Neri Alvarez-Villalobos, Francisco Jesús Barrera-Flores, Alejandro Díaz González-Colmenero, Carolina Quintanilla-Sánchez, Victor M. Montori, Rene Rodriguez-Gutierrez   +7 more
openaire   +5 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source