Results 131 to 140 of about 123,080 (305)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Systematics of eocrinoid echinoderms [PDF]
, 2011 This work deals with systematics of eocrinoid echinoderms but also with their morphology and classification within the echinoderms. Two theories concerning systematic of eocrinoid echinoderms are compiled in this work.
Nohejlová, Martina
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Mitogenome characterization and phylogeny of Neohydatothrips gracilipes (Thripidae: Sericothripinae)
Scientific ReportsThrips are tiny, fringe-winged insects acting as serious pests and vectors of Tospoviruses in agroecosystems. The second complete mitogenome of the subfamily Sericothripinae, Neohydatothrips gracilipes (14,999 bp), was generated by the next-generation ...
Abhishek Ghosh +7 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Study of school zones with traffic signals : final report, June 2009.
C8L13One of the most pressing and controversial problems faced by parents, school administrators, law enforcement and transportation professionals throughout the country is the safety of children on their way to and from school.
Cambridge Systematics
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
PLANCK 2015 OVERVIEW & SYSTEMATICS [PDF]
, 2015 I will give an overview of the Planck 2015 results and discuss the most important systematics affecting the two instrumentsLawrence, Charles. (2015). PLANCK 2015 OVERVIEW & SYSTEMATICS.
Lawrence, Charles
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source